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Branched block copolymer photocrosslinkers functionalized with photoreactive groups and their use in shaping degradable photocrosslinked elastomers suitable for medical and tissue engineering applications

A block copolymer, photoreactive technology, applied in the field of new degradable branched block copolymers, which can solve problems such as low crosslinking efficiency

Pending Publication Date: 2022-04-26
UNIVERSITY OF MONTPELLIER +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the disclosed photocrosslinker bis(aryl azide) 2,6-bis(azidobenzylidene)-4-methylcyclohexanone leads to low crosslinking efficiency, especially when the target material When the thickness exceeds 10μm

Method used

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  • Branched block copolymer photocrosslinkers functionalized with photoreactive groups and their use in shaping degradable photocrosslinked elastomers suitable for medical and tissue engineering applications
  • Branched block copolymer photocrosslinkers functionalized with photoreactive groups and their use in shaping degradable photocrosslinked elastomers suitable for medical and tissue engineering applications
  • Branched block copolymer photocrosslinkers functionalized with photoreactive groups and their use in shaping degradable photocrosslinked elastomers suitable for medical and tissue engineering applications

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Embodiment

[0187] 1. Materials and Methods

[0188] 1.1 Materials

[0189] D, L-lactide and L-lactide were purchased from Purac (Lyon, France). 8-armed poly(ethylene glycol) (tripentaerythritol) (PEG 8臂 10k, Mw=10000g.mol -1 ) was purchased from JenKem Technology Co., Ltd. (Beijing, China). Poloxamer ( F127, Mw=12600g.mol -1 ), tin(II) 2-ethylhexanoate (Sn(Oct) 2 ,95%), dichloromethane (DCM), diethyl ether (Et 2 O), N,N-dicyclohexyl-carbodiimide (DCC), 4-(dimethylamine)pyridine (DMAP) and N,N-dimethylformamide (DMF), tetrahydrofuran (THF) were purchased from Sigma-Aldrich (St Quentin Fallavier, France). 2,6-Bis(4-azidobenzylidene)-4-methylcyclohexanone (BA) and 4-azidobenzoic acid were purchased from TCI (Paris, Europe). All chemicals except DCM and DCC were used without further purification. DCM was dried from calcium hybrid and used freshly distilled. DCC through MgSO 4 Dissolved in anhydrous DCM, stirred for 6 hours, then filtered and dried for use.

[0190] 1.2 Characte...

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Abstract

The present invention relates to novel degradable branched block copolymers comprising a star copolymer central core or a linear copolymer central core functionalized with a photoreactive group selected from aryl azide groups, (meth) acrylate groups or thiol groups. The invention also relates to the use of these degradable branched block copolymers as photocrosslinkers for providing degradable photocrosslinked elastomers, which are suitable as biomaterials for medical and tissue engineering applications. Also provided is a method for preparing a degradable photo-crosslinked polymer, preferably a degradable photo-crosslinked elastomer, starting from the branched block copolymer of the invention by a shaping process and irradiation step.

Description

technical field [0001] The present invention relates to novel degradable branched block copolymers (especially star copolymers) functionalized with photoreactive groups selected from aryl azido groups, (meth)acrylate groups or thiol groups, And the use of the degradable branched block copolymer as a photocrosslinking agent for providing a degradable photocrosslinkable elastomer suitable for medical applications and tissue engineering applications as biomaterials. Background technique [0002] Polymeric materials are widely used in medical devices. Depending on their use, degradable polymers with elastic properties are desired, especially in the field of tissue engineering. Such (bio)absorbable materials solve the problems associated with biostable materials, whose long-term existence is often problematic, while producing minimal long-term inflammation. [0003] Biodegradable polymeric materials are usually composed of thermoplastic polymers or cross-linked materials. In p...

Claims

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Application Information

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IPC IPC(8): C08G65/26C08G65/333C08G63/664
CPCC08G63/664C08G65/2615C08G65/33396C08G81/025C08G2230/00C08J3/24C08J2353/00
Inventor X·加里克F·博萨尔L·甘戈尔夫B·诺泰莱
Owner UNIVERSITY OF MONTPELLIER
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