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Compressible non-fibrous adjunct

An appendage, compressive strength technology, used in nails, medical science, surgery, etc., can solve problems such as lack of tissue characteristics, no thickness, tissue tearing, etc.

Pending Publication Date: 2022-04-29
CILAG GMBH INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in some cases, the tissue being stapled does not have a consistent thickness, so the staples cannot achieve the desired firing configuration at each staple site
As a result, the desired seal does not form at or near all suture sites, allowing blood, air, gastrointestinal fluids, and other fluids to seep through the unsealed site
[0006] Additionally, staples that are recessed channels, like other objects and materials that can be implanted in conjunction with suture-like procedures, often lack some of the properties of the tissue in which they are implanted
For example, staples and other objects and materials can lack the natural flexibility of the tissue in which they are implanted and therefore cannot withstand the different pressures within the tissue at the implantation site
This can lead to undesired tearing of tissue at or near the suture site, and thus leakage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0428] Examples 1-3: Preparation of Bifunctional Methacrylate (MA) Terminated Polyester Oligomer

[0429] Examples 1-3 describe the preparation of bifunctional methacrylate terminated polyester oligomers. The middle block is PLGA-PCL-PLGA with a molecular weight of 6 kilodaltons, and PCL accounts for 40 wt.% of the total molecular weight (MW). PLGA is a random copolymer of lactide (L) and glycolide (G), in which the weight ratio of L:G is 1:1.

[0430] The molar ratio and mass of each reagent used to synthesize a 1kg batch of HO-PLGA-b-PCL-b-PLGA-OH as discussed in Example 1 and Example 2 are provided in Table 3 below.

Embodiment 1

[0433] Example 1: synthesis of ho-PCL-oh

[0434] The round-bottom flask was dried overnight in a drying oven and dried in N. 2 Downstream cooling to room temperature. Caprolactone and stannous octoate were added into the round-bottom flask via a glass syringe and syringe needle. The content of that reaction flask were heated to 130. degree. C.. Meanwhile, diethylene glycol was heated to 130℃. After preheating, diethylene glycol was added to the reaction flask as an initiator and allowed to react until the monomer conversion was complete. Use h 1 Monitor monomer conversion by NMR. Once the complete monomer conversion rate is reached, the reaction is stopped and the reaction content is cooled to room temperature. HO-PCL-OH was precipitated from chloroform into cold MeOH to obtain a white solid. H 1 NMR, DSC, FTIR and THF GPC were used to characterize HO-PCL-OH.

Embodiment 2

[0435] Example 2: synthesis of ho-PLGA-b-PCL-b-PLGA-oh

[0436] HO-PCL-OH prepared in Example 1 was mixed with different amounts of D,L- lactide and glycolide in N 2 Added into a round bottom flask and heated to 140℃ to melt the reaction contents. After melting, the temperature was reduced to 120℃ and stannous octoate was added. The reaction was continued under stirring, while H. 1 And the monomer conversion was monitored by NMR and THF GPC. Once the reaction reaches the required molecular weight, the reaction contents are cooled to room temperature, dissolved in chloroform, and precipitated in cold ether for three times. The precipitate was dried under vacuum.

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Abstract

A stapling assembly for use with a surgical stapler is provided. In one exemplary embodiment, the stapling assembly includes a cartridge having a plurality of staples disposed therein, and a non-fibrous adjunct formed from at least one molten bioabsorbable polymer and configured to be releasably retained on the cartridge. An adjunct system for use with a surgical stapler is also provided. A surgical end effector using the stapling assembly is also provided. Methods for making and using the stapling assemblies are also provided.

Description

[0001] Cross-references to related applications [0002] This application claims U.S. provisional patent applicationNo. 62 / 900, filed on Sep. 16, 2019 and entitled "Bio-absorbable resin for additive manufacturing", 08. Priority of U.S. Provisional Patent ApplicationNo. 62 / 913,227 filed on October 10, 2019 and U.S. Provisional Patent ApplicationNo. 63 / 053,863 filed on July 20, 2020, the disclosures of which are all incorporated by reference. Technical field [0003] Compressible non-fibrous appendages and methods of making and using the same are provided. technical background [0004] Surgical staplers are used in surgical operations to close openings in tissues, blood vessels, catheters, shunt tubes, or other objects or body parts involved in a particular operation. These openings may be naturally occurring, such as passageways in blood vessels or internal organs similar to the stomach, or they may be formed by surgeons during surgical procedures, such as by puncturing tissues or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/068A61B17/072A61B17/064A61L17/12
CPCA61B17/0686A61B17/072A61B17/064A61B17/07292A61B17/07207A61B17/0644A61L17/12A61B2017/07257A61B2017/07228A61B2017/07271A61B2017/07285A61B2017/07278A61B2017/07235A61B2017/00889A61B2017/00004A61B2017/07242A61B2017/00849
Inventor J·L·哈里斯M·J·温德里F·E·谢尔顿四世
Owner CILAG GMBH INT