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A kind of biomimetic biological glue and its preparation method and application

A bio-glue and bio-polymer technology, applied in the field of biomimetic bio-glue and its preparation, can solve problems such as difficulty in matching irregular shapes, difficult tissue or wound repair, and inability to bond on wet surfaces, improving hemostatic performance and easy operation. , preparation method green effect

Active Publication Date: 2022-06-17
WUQI BIOMEDICAL TECH (JIANGSU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing bioglues have the following problems: (1) toxicity; (2) inability to bond to wet surfaces; (3) weak adhesion; (4) difficult to match irregular shapes of defects, etc.
For example, super glue (cyanoacrylic adhesive) has strong adhesion to tissue, but it is difficult to use in tissue or wound repair due to its strong cytotoxicity; wet surface is also the main cause of adhesion failure, due to human body In the presence of body fluids, it is crucial to find bioglues that can also adhere in a liquid environment; weak adhesion often leads to excessive friction on the tissue bonding surface, resulting in inflammation or directly causing the adhesive to fall off. Ultimately lead to bond failure; other new synthetic gels, although highly adhesive to tissue, are difficult to use clinically due to the presence of toxic initiators and activators

Method used

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  • A kind of biomimetic biological glue and its preparation method and application
  • A kind of biomimetic biological glue and its preparation method and application
  • A kind of biomimetic biological glue and its preparation method and application

Examples

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preparation example Construction

[0041] Another aspect of the embodiments of the present invention also provides the aforementioned preparation method of biomimetic biological glue, which includes:

[0042] reacting a first mixed reaction system comprising dopamine hydrochloride, an amino-containing biopolymer, NHS, EDC, trifluoroacetic acid and / or acetic acid to prepare the dopamine-modified amino-containing biopolymer;

[0043] A second mixed reaction system containing p-benzaldehyde, a hydroxyl-containing biopolymer, 2,2-dimethylolpropionic acid, dicyclohexylcarbodiimide and tetrahydrofuran is reacted in a closed environment to prepare the aldehyde of hydroxyl-containing biopolymers;

[0044] And, mixing the dopamine-modified amino-containing biopolymer, hydroxyl-containing biopolymer, and aldehyde-based hydroxyl-containing biopolymer evenly, then adding a metal chloride salt and mixing it with a solvent, and then incubating for 10- The biomimetic bio-glue was prepared by spontaneous biomineralization or ex...

Embodiment 1

[0075]Weigh 500 mg of collagen and dissolve it in 50 mL of 0.5wt% trifluoroacetic acid, stir at room temperature for 2-3 hours to form a collagen solution, then add 0.5 g of dopamine hydrochloride to the collagen solution, and stir and dissolve under airtight conditions At the same time, the pH value of the mixed solution was adjusted to 5.5 by adding 1 mol / L sodium hydroxide solution dropwise; then 0.85 g of NHS was weighed and dissolved in 15 mL deionized water to form an NHS solution, and 1 mol / L sodium hydroxide was added dropwise at the same time. solution to adjust the pH value of the mixed solution to 5.5, also weigh 1.15g of EDC and dissolve it in 15mL of deionized water to form an EDC solution, and adjust the pH value of the mixed solution to 5.5 by adding 10wt% trifluoroacetic acid solution dropwise; The prepared NHS and EDC solutions were added to the mixed solution with an interval of 15 minutes. After that, the entire reaction system was placed in a closed environm...

Embodiment 2

[0080] Weigh 1000 mg of chitosan and dissolve it in 50 mL of 0.5 wt% trifluoroacetic acid, stir at room temperature for 1-2 hours to completely dissolve to form a chitosan solution, then add 0.6 g of dopamine hydrochloride to the chitosan solution, and Stir and dissolve under airtight conditions, and adjust the pH value of the mixed solution to 5.5 by adding 1 mol / L sodium hydroxide solution dropwise; then weigh 0.85 g of NHS and dissolve it in 15 mL of deionized water to form an NHS solution. 1mol / L sodium hydroxide solution to adjust the pH value of the mixed solution to 5.5, also weigh 1.15g of EDC and dissolve it in 15mL of deionized water to form an EDC solution, and adjust the pH of the mixed solution by adding 10wt% trifluoroacetic acid solution dropwise value to 5.5; sequentially add the prepared NHS and EDC solutions to the mixed solution with an interval of 15 minutes, then place the entire reaction system in a closed environment, and react at room temperature for 20h...

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Abstract

The invention discloses a bionic biological glue, a preparation method and application thereof. The biomimetic biological glue includes the following components: dopamine-modified amino-containing biopolymer, hydroxyl-containing biopolymer, aldylated hydroxyl-containing biopolymer, chloride metal salt and solvent. The bionic bio-adhesive of the present invention has excellent biocompatibility, electrical conductivity, wet surface adhesion, injectability, self-healing, biodegradability, hemostasis and healing-promoting ability; The spontaneous biomineralization of metal cations in bioglue achieves network enhancement and adhesion enhancement. The introduction of biomineralized metal particles significantly improves the hemostatic performance of the material. Together with dopamine-modified amino-containing biopolymers and hydroxyl-containing The synergy of biopolymers for rapid hemostasis makes this biomimetic organism have broad application prospects in the fields of biomedicine and tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a biomimetic biological glue and a preparation method and application thereof. Background technique [0002] Recently, bioglue is considered to be a promising material class due to its gradual application in biomedical devices such as tissue adhesion, wound repair, tissue repair, rapid hemostasis, drug delivery, and cosmetic filling. However, the existing bioadhesives have the following problems: (1) toxicity; (2) inability to bond to wet surfaces; (3) weak adhesion; (4) difficult to match irregular shapes of defects, etc. For example, super glue (cyanoacrylic adhesive) has strong adhesion to tissue, but it is difficult to be used for tissue or wound repair due to its strong cytotoxicity; wet surfaces are also the main cause of adhesion failure, because the human body In the presence of body fluids, it is crucial to find a biological glue that can adhere...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/56A61L26/00A61L24/04A61L24/02
CPCA61L27/56A61L27/50A61L27/446A61L26/0085A61L26/0095A61L26/0061A61L24/0036A61L24/0089A61L24/001A61L2300/418A61L2400/06A61L2400/04
Inventor 戴建武陈艳艳杨文
Owner WUQI BIOMEDICAL TECH (JIANGSU) CO LTD
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