Biomarker and kit for identifying sepsis infection type

A biomarker and complete set of technology, applied in biological testing, bioinformatics, biostatistics, etc., can solve problems such as lack of biomarkers

Pending Publication Date: 2022-05-03
YANTAI YUHUANGDING HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0010] However, biomarkers and related tools obtained through the new generation of targeted metabolomics are still lacking in the field, so as to quickly and accurately identify the type of sepsis or the pathogens causing sepsis and formulate precise treatment plans in clinic. in accordance with

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  • Biomarker and kit for identifying sepsis infection type
  • Biomarker and kit for identifying sepsis infection type
  • Biomarker and kit for identifying sepsis infection type

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Embodiment Construction

[0041] The technical solutions and beneficial effects of the present invention will be further described below in conjunction with specific embodiments.

[0042] Sepsis is still a thorny problem in critical care medicine today, with a high mortality rate. Correct identification of sepsis caused by different pathogens and timely administration of effective anti-infective treatment are the keys to improving the success rate of sepsis rescue. Therefore, integrating multi-omics and multi-dimensional data and using machine learning algorithms to find pathogen-specific molecular patterns and markers is a key scientific problem to be solved by the present invention. Aiming at this key scientific problem, the present invention preliminarily explored a set of algorithm flow for integrating multi-omics and multi-dimensional data through 100 cases of sepsis patients infected by Gram-negative bacteria. By analyzing the patient's serum metabolism and comparing it with other types of infec...

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Abstract

The invention provides an application of a blood metabolite in preparation of a biomarker for distinguishing sepsis infection types and a related kit. Wherein the blood metabolite comprises at least one of 4-pyridoxine, cholesterol sulfate, indole sulfate, L-homocysteine, succinylcholine carnitine, phosphoenolpyruvic acid, plasmalogen (p18: 0 / 20: 4), uridine, taurine, and flavin. The biomarker can be used for effectively distinguishing microbial infection types of sepsis, guiding clinical rapid adoption of an effective treatment scheme and reducing the death rate of sepsis, and has the advantages of noninvasive property, accuracy, early stage and high precision.

Description

technical field [0001] The present invention relates to the field of diagnosis of diseases, in particular to a biomarker for the diagnosis of sepsis and related kits, such as a diagnostic kit. Background technique [0002] Sepsis is a life-threatening organ dysfunction caused by an uncontrolled host response to infection. Sepsis is a thorny problem facing critical care medicine today and has become one of the leading causes of death in critically ill patients. Sepsis is also an important cause of death from the COVID-19 novel coronavirus infection currently in the global pandemic. [0003] The rapid identification of pathogens in sepsis infection is an important basis for clinically formulating precise treatment plans. The main pathogens of sepsis include bacteria, fungi, viruses, and parasites. Whether the pathogens can be identified in time and targeted anti-infective treatment is closely related to the prognosis of patients with sepsis. Clinically, early diagnosis, tre...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N33/68G16B20/00G16B40/00G16H50/20G16H70/60
CPCG01N30/02G01N30/06G01N30/72G01N33/6848G16H50/20G16H70/60G16B40/00G16B20/00
Inventor 王静李克峰
Owner YANTAI YUHUANGDING HOSPITAL
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