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Brain dopamine transporter examination system and operation method thereof

An inspection system and operation method technology, applied in the system field, can solve problems such as differences in interpretation results, and achieve the effect of improving the diagnosis rate and treatment results

Pending Publication Date: 2022-05-03
TAIPEI MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Nuclear medicine examinations are functional imaging examinations, which mainly use visual reading combined with semi-quantitative Specific Binding Ratio analysis for image diagnosis. The above-mentioned reasons such as brightness and contrast, human eye fatigue, and interpreters with different experience may produce a certain degree of difference in the interpretation results

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  • Brain dopamine transporter examination system and operation method thereof
  • Brain dopamine transporter examination system and operation method thereof

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Embodiment Construction

[0030] In order to make the description of the present invention more detailed and complete, reference may be made to the attached drawings and various embodiments described below, and the same numbers in the drawings represent the same or similar elements. On the other hand, well-known elements and steps have not been described in the embodiments in order to avoid unnecessarily limiting the invention.

[0031] In the embodiments and claims, the description related to "connection" may generally refer to an element being indirectly coupled to another element through other elements, or an element being directly connected to another element without passing through other elements.

[0032] In the embodiments and claims, the description related to "connection" may generally refer to a component indirectly conducting wired and / or wireless communication with another component through other components, or a component is physically connected without passing through other components to ...

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Abstract

The invention provides an operation method of a brain dopamine transporter examination system. The operation method comprises the following steps of: 1, detecting a brain dopamine transporter; acquiring a scanning image of the brain of the testee from the scanner, wherein the scanning image is a three-dimensional image; aligning the scanning image to a standard brain space to obtain a normalized scanning image; performing image intensity standardization on the normalized scanning image; converting the normalized scanning image after the image intensity standardization into a two-dimensional image; cutting out a plurality of image data for at least one region of interest of the two-dimensional image, wherein the region of interest comprises a left side tail core, a left side shell core, a right side tail core and a right side shell core; based on a plurality of image data, a dopaminergic neuron loss degree measurement evaluation model is established by transfer learning, so that the images are classified in the most probable neuron loss stage, an additional auxiliary diagnosis mode is provided for nuclear medical doctors to interpret brain dopamine transporter examination every time, and the accuracy of brain dopamine transporter examination is improved. And the diagnosis rate and the treatment result of clinicians are improved.

Description

technical field [0001] The present invention relates to a system and its method, and in particular to a brain dopamine transporter inspection system and its operating method. Background technique [0002] Parkinson's Disease (PD) is a chronic neurodegenerative disease affecting the central nervous system, mainly affecting the motor nervous system. Symptoms usually develop slowly over time, with tremors, stiffness, hypokinesia, and abnormal gait being the most obvious early symptoms, which may also be accompanied by cognitive and behavioral problems. The main pathological changes of Parkinson's disease occur in the substantia nigra compacted part of the midbrain. This area contains a large number of dopamine neurons and transmits information to the basal ganglia of the brain. The main symptoms of Parkinson's disease are precisely because of the compact substantia nigra Caused by the degeneration of dopamine neurons in the brain. [0003] In clinical practice, although Parki...

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Application Information

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IPC IPC(8): G06T7/00G06T7/11G16H50/20G06N3/08A61B5/055A61B5/00G06V10/25G06V10/82
CPCG06T7/0012G06T7/11A61B5/055A61B5/4082A61B5/7264G06N3/08G16H50/20G06T2207/30016G06T2207/10088G06T2207/20084
Inventor 彭徐钧陈信咏蔡雅茹
Owner TAIPEI MEDICAL UNIV
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