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Thermosensitive hydrogel composition for preventing tissue adhesion and preparation method thereof

A technology of tissue adhesion and hydrogel, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of low efficacy of anti-adhesion agents and achieve excellent biodegradability Effect

Inactive Publication Date: 2022-05-17
REGEN BIOCHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in the case of using a gel-type anti-adhesion agent, it is known that wound healing at the surgical site usually takes about 7 days. However, before the wound heals, it is easily decomposed and absorbed into the body (aqueous solution form), , has the problem of low efficacy as an anti-adhesion agent (J.M.Becker, et al., presented at clinical congress of Am. College of surgeon, New of leans, October 22(1995))
[0006] As mentioned above, although many researches have been carried out to prevent tissue adhesion after surgery, when using the existing anti-adhesion agent that cannot improve the above-mentioned problems, it is difficult to show the effect corresponding to the high cost, so there is still a need. Continue to develop new concepts of anti-blocking agents

Method used

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  • Thermosensitive hydrogel composition for preventing tissue adhesion and preparation method thereof
  • Thermosensitive hydrogel composition for preventing tissue adhesion and preparation method thereof
  • Thermosensitive hydrogel composition for preventing tissue adhesion and preparation method thereof

Examples

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preparation example Construction

[0057] Further, the preparation method of the hydrogel composition of the present invention for preventing tissue adhesion comprises: a copolymer dissolution step, a molecular weight of 1 kDa to 500kDa polyethylene oxide - polyethylene oxide - polyethylene oxide ternary copolymer heated at a temperature of 60 ° C to 100 ° C for 1 hour to 2 hours to dissolve; hyaluronic acid mixing step, in the lysol prepared by the above copolymer dissolution step mixed water insoluble hyaluronic acid and stirred at a temperature of 10 ° C to 20 ° C and the sodium alginate mixing step, in a mixture prepared by the above hyaluronic acid mixing step mixing sodium alginate and stirred at a temperature of 5 ° C to 20 ° C.

[0058] In the above copolymer dissolution step, the molecular weight of 1 kDa to 500kDa polyethylene oxide - polyethylene oxide - polyethylene oxide terpolymer at a temperature of 60 ° C to 100 ° C heating for 1 hour to 2 hours to dissolve, in this case, with respect to the total w...

Embodiment 113

[0103] Example 113. Preparation of levo-polylactic acid granules, polylactic acid - hydroxyacetic acid copolymer particles, polydioxaneketone granules and polycaprolactone granules

[0104] In the above-described embodiments 65 to 112, with respect to the ternary copolymer added biodegradable polymer to achieve granulation, in the case of no water insoluble hydrogel, using distilled water washed more than 3 times, subsequently, under temperature conditions below -70 ° C frozen and freeze-dried at a temperature of -45 ° C and 1 millibar (mbar) pressure conditions to prepare particles.

experiment example 1

[0106] Visually confirm the uniformity of the hydrogel composition prepared in the above examples 1 to 16 to prevent tissue adhesion, the results of which are shown in Table 9 below.

[0107] Table 9

[0108]

[0109] As shown in Table 9 above, if the content of the ternary copolymer is less than 15 percent by weight or greater than 30 percent by weight, the state of the hydrogel composition cannot be made uniform, and when the concentration of water-insoluble hyaluronic acid is less than 2.5 percent by weight or greater than 4.5 percent by weight, the uniformity of the hydrogel composition cannot be ensured.

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Abstract

The invention relates to a hydrogel composition for preventing tissue adhesion and a preparation method thereof, and the hydrogel composition for preventing tissue adhesion provided by the invention comprises a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer, water-insoluble hyaluronic acid, sodium alginate and purified water, the preparation method comprises: a copolymer dissolution step of dissolving a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer having a molecular weight of 1 kDa to 500 kDa by heating at a temperature of 60 DEG C to 100 DEG C for 1 to 2 hours; a hyaluronic acid mixing step in which water-insoluble hyaluronic acid is mixed with the solute prepared by the copolymer dissolving step and stirred at a temperature of 10-20 DEG C; and a sodium alginate mixing step in which sodium alginate is mixed in the mixture prepared by the hyaluronic acid mixing step and stirred at a temperature of 5 DEG C to 20 DEG C. According to the hydrogel composition for preventing tissue adhesion and the preparation method thereof, a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer with a tissue adhesion inhibiting effect is used as a basic structure body, and water-insoluble hyaluronic acid is mixed in the basic structure body; sodium alginate is used to provide a hydrogel composition for preventing tissue adhesion, which can be uniformly applied to an injured part of a body.

Description

Technical field [0001] The present invention relates to a hydrogel composition for preventing tissue adhesion and a preparation method thereof, in more detail, relates to the following hydrogel composition for preventing tissue adhesion and a preparation method thereof, i.e., a polyethylene oxide - polyethylene oxide - polyethylene oxide ternary copolymer having a tissue adhesion inhibition effect as the basic structure, wherein mixed with water-insoluble hyaluronic acid, sodium alginate to provide a hydrogel composition capable of uniformly applying to the injured part of the body for preventing tissue adhesion. Background [0002] Usually, the adhesion of organs to tissues produced after surgery is one of the natural phenomena that occur during the proliferation and regeneration of cells of damaged tissues, but strong tissue adhesions or accidental adhesions to other tissues and organs will cause patients to continue to feel discomfort or cause dysfunction. Moreover, since sur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/14A61L31/16
CPCA61L31/041A61L31/145A61L31/148A61L31/16A61L2300/416A61L2300/604C08L71/02C08L5/04C08L5/08C08L67/04A61L31/042A61K31/7068A61K47/34A61P35/00
Inventor 金庚均崔明金相镇
Owner REGEN BIOCHARM CO LTD