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Felodipine penetration enhancer combination, felodipine transdermal delivery preparation and transdermal delivery device

A technology of felodipine and dipine meridian, which is applied in the direction of drug combination, drug delivery, and medical preparations of non-active ingredients, etc. It can solve problems such as gastrointestinal irritation and unstable drug effect, reduce side effects and improve compliance Effect

Pending Publication Date: 2022-06-03
鑫稳生物医药科技(嘉善)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral administration is often complicated by gastrointestinal irritation, drug metabolism in the liver and the influence of food leading to unstable drug efficacy

Method used

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  • Felodipine penetration enhancer combination, felodipine transdermal delivery preparation and transdermal delivery device
  • Felodipine penetration enhancer combination, felodipine transdermal delivery preparation and transdermal delivery device
  • Felodipine penetration enhancer combination, felodipine transdermal delivery preparation and transdermal delivery device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Sample Components of Example 1

[0051]

[0052] The preparation technique of embodiment 1 is as follows:

[0053] Weigh the corresponding felodipine, excipients, penetration enhancer, and pressure-sensitive adhesive into a container in order, and use the stirring method of rotating and shaking for more than 4 hours.

[0054]Franz diffusion cell was used for percutaneous diffusion, the diffusion condition was 32°C, the receiving solution was a buffer solution with 40% methanol added, and the samples were detected by HPLC. figure 1 shown.

example 2

[0056] The samples were prepared according to the following recipes

[0057]

[0058] The preparation process is as follows

[0059] Weigh the corresponding felodipine, excipients, penetration enhancer, and pressure-sensitive adhesive into a container in order, and use the stirring method of rotating and shaking, and stir for more than 4 hours.

[0060] Franz diffusion cell was used for percutaneous diffusion, the diffusion condition was 32°C, the receiving solution was a buffer solution with 40% methanol added, and the samples were detected by HPLC. figure 2 shown.

example 3

[0062] The samples were prepared according to the following recipes

[0063]

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PUM

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Abstract

The invention discloses a felodipine penetration enhancer combination, a felodipine transdermal delivery preparation and a transdermal delivery device, the felodipine penetration enhancer combination at least comprises two or more of the following components in parts by weight: compared with the prior art, the felodipine penetration enhancer combination has the following beneficial effects: the penetration flux can be improved by 20-400% by the felodipine penetration enhancer combination. The transdermal drug delivery device combined with the penetration enhancer can obviously improve the skin penetration flux of felodipine in 24 hours and longer time. The transdermal drug delivery device can increase the cumulative skin permeation flux of 24 hours to 50 micrograms / cm < 2 > or more.

Description

technical field [0001] The invention relates to the technical field of medicaments, a combination of felodipine penetration enhancers and a device for transdermal delivery. The felodipine penetration enhancer combination can significantly improve the skin administration of felodipine and enhance the skin permeation flux. Background technique [0002] High blood pressure is a serious health hazard. Long-term increases in blood pressure can damage the heart, causing changes in the structure and function of the heart. For hypertensive patients, it is very important to use safe, effective and convenient long-term blood pressure lowering products to maintain stable blood pressure and cardiovascular system health for a long time. [0003] The chemical name of felodipine is (±)-2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate methyl ethyl ester, It is a vascular selective calcium channel blocker, which is highly selective for arterial smooth muscle, has ...

Claims

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Application Information

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IPC IPC(8): A61K47/14A61K47/12A61K47/10A61K47/18A61K47/32A61K9/00A61K9/70A61K31/4422A61P9/12A61M37/00
CPCA61K47/14A61K47/12A61K47/10A61K47/183A61K47/32A61K9/0014A61K9/7023A61K31/4422A61P9/12A61M37/00
Inventor 岳洋徐壁雄马丹丹
Owner 鑫稳生物医药科技(嘉善)有限公司
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