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Composition for delivery of nitric oxide to skin

A composition, skin technology, applied in the direction of skin care preparations, drug combinations, skin diseases, etc., can solve problems such as spending hours/days

Pending Publication Date: 2022-06-03
INSENSE LIMITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, while nitrosocysteine ​​can be fully broken down within minutes under normal conditions, it takes hours / days to achieve 100% breakdown of nitrosoglutathione

Method used

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  • Composition for delivery of nitric oxide to skin
  • Composition for delivery of nitric oxide to skin
  • Composition for delivery of nitric oxide to skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0068] To demonstrate the release rate of S-nitrosothiols, a number of model systems were prepared. These systems are detailed in the tables at the beginning of each results section below. For each system, sample aliquots were taken from the aqueous components at three time points after the system was 'activated' (ie all components were placed together) to confirm the presence of S-nitrosothiol release. The first time point is always t=zero (ie, before 'activating' with the dry / non-aqueous component, measure the S-nitrosothiol in the aqueous component to demonstrate the absence of S-nitroso at the beginning thiol, in all systems), then t = 2 hours after activation, and finally t = 6 hours after activation.

[0069] Material

[0070] Sodium nitrite in DI water (300mM)

[0071] Glutathione in DI water (300mM)

[0072] Lactic acid (100mM) in DI water - (adjusted to pH 4.0 with 0.2M NaOH)

[0073] · Sorbitol in DI water (1M)

[0074] Polyvinyl alcohol in Polyvinyl DI water ...

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Abstract

A dermatological application composition is provided that includes a first component comprising S-nitrosothiol in a dry inactive state.

Description

technical field [0001] The present invention relates to a treatment composition for application (for therapeutic or cosmetic purposes) to a part of the human or animal body, ie a skin dressing. Background technique [0002] Nitric oxide is an essential signaling molecule in mammals and is known to play a variety of roles, ranging from regulating blood flow, neurotransmission, and immune responses. Importantly, a special family of enzymes called nitric oxide synthases have evolved to make controlled amounts of nitric oxide using the amino acid arginine as a precursor when and where nitric oxide is needed exclusive work. [0003] However, nitric oxide is a very hydrophobic compound, and so its solubility in water is limited. Under normal conditions, the maximum achievable solubility in water is approximately about 1.7 mM, which is similar to that of oxygen. [0004] Nitric oxide also reacts rapidly with oxygen to form nitrogen dioxide. Nitrogen dioxide has no known role in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/46A61K8/19A61Q19/00A61K9/00A61K9/70A61P17/00
CPCA61K8/46A61K8/19A61Q19/00A61K9/0014A61K8/0208A61K9/7023A61K47/02A61K31/095A61K33/00A61P17/02A61K2800/10A61K9/70A61L15/24A61L15/44A61K8/0233A61K8/23A61K9/7092A61K2800/88
Inventor J·耶泽克P·戴维斯
Owner INSENSE LIMITED