Sodium aescinate compound preparation for injection

The technology of aescin sodium and compound preparation, which is applied in the field of medicine, can solve the problems of high incidence of adverse reactions and low incidence of adverse reactions, and achieve the effects of reducing the incidence of adverse reactions, reducing irritation and long storage period

Active Publication Date: 2022-06-07
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problem of high incidence of adverse reactions commonly existing in the clinical use of existing products, and provide a safe and effective compound preparation of sodium aescinate for injection with a low incidence of adverse reactions

Method used

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  • Sodium aescinate compound preparation for injection
  • Sodium aescinate compound preparation for injection
  • Sodium aescinate compound preparation for injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0017] Sodium aescin for injection per 1000 sticks:

[0018]

[0019] Preparation method:

[0020] 1, ingredients: 10.0g of sodium aesparabonin is added to 400ml of 60 ° C below the injection water to dissolve, dissolve and clarify after adding the prescription amount of glycyrrhizinate monoammonium, continue to stir until dissolved and clarified, make up the injection water to 500ml.

[0021] 2. Filtration: The liquid medicine is first filtered through the 0.45um PES filter membrane, and then filtered by the 0.22um filter membrane.

[0022] 3, filling: the liquid medicine into the cleaning and sterilization of drying treatment of 2ml of the bottle, 0.5ml / stick, and after cleaning and sterilization drying treatment bromide butyl rubber stopper, semi-pressure plug, leaving 2 ~ 3mm of air holes.

[0023] 4. Lyophilization: Put all the filled samples into the lyophilized plate layer, set the lyophilization parameters to start running, and the lyophilization parameters are as foll...

Embodiment 5

[0030] Sodium aescin for injection per 1000 sticks:

[0031] prescription Dosage Aesparabonin sodium 10.0g Diammonium glycyrrhizinate 100.0g Water for injection to 1000ml

[0032] Preparation method:

[0033] 1, ingredients: 10.0g of sodium horse chestnut saponin added to 800ml of 60 ° C below the injection water dissolved, dissolved and clarified after adding 100.0g of ammonium glycyrrhizinate, continue to stir until dissolved and clarified, make up the injection water to 1000ml.

[0034] 2. Filtration: The liquid medicine is first filtered through the 0.45um PES filter membrane, and then filtered by the 0.22um filter membrane.

[0035] 3, filling: the liquid medicine into the cleaning and sterilization of drying treatment of 2ml of cylin bottle, 1.0ml / stick, and after cleaning and sterilization of drying brominated butyl rubber stopper, semi-pressure plug, leaving 2 ~ 3mm of air outlet holes.

[0036] 4. Lyophilization: Put all the filled samples i...

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Abstract

The invention discloses a sodium aescinate compound preparation for injection, which contains sodium aescinate and glycyrrhizinate, and belongs to the field of medicines. According to the sodium aescinate injection, the problem that the occurrence rate of untoward effects is high generally existing in clinical use of an existing sodium aescinate product for injection is solved, irritation of blood vessels and injection parts caused by injection of the sodium aescinate is reduced, and meanwhile the anti-swelling curative effect of the sodium aescinate is improved.

Description

Technical field [0001] The present invention belongs to the field of medicine, specifically relates to a combination formulation of sodium aesparabonin for injection. Background [0002] Sodium acin is a saponin sodium salt extracted from dried mature seeds (collectively known as brahmin) of the family Aesculus Chinese Bge) or Aesculus Wilsonii Rehd. It has the effect of anti-exudation and increasing venous tone, reducing swelling, anti-inflammatory and improving blood circulation. Clinical applications are widespread, mainly used for cerebral edema, trauma or swelling caused by surgery, and also for venous reflux disorders. [0003] With the increasingly widespread use of sodium aesparabonin for injection, the number of adverse reaction reports of sodium aescin for injection received by the National Adverse Drug Reaction Monitoring Center has gradually increased, of which from January 2004 to June 2019, the National Adverse Drug Reaction Monitoring Database has received more tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K47/28A61K31/704A61P7/10
CPCA61K9/19A61K9/0019A61K47/28A61K31/704A61P7/10A61K2300/00Y02A50/30
Inventor 施川关小羽刘华侨孙天鹏许攀韩攀熊建军刘享平
Owner WUHAN AIMIN PHARMA
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