Furanone preparation system and preparation method

A preparation system and technology of furanone, which is applied in the preparation system and field of furanone, can solve the problems of low yield and difficult industrial production and operation of raw materials, achieve cheap raw materials, reduce washing times and waste water discharge, and reduce risks The effect of the coefficient

Pending Publication Date: 2022-06-07
宁夏万香源生物科技有限公司
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Problems solved by technology

[0004] In view of this, it is necessary to provide a preparation system for furanone to solve the problem that the yield of the intermediate α-

Method used

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preparation example Construction

[0051] A preparation method of furanone, utilizing the above-mentioned furanone preparation system 10 to prepare, comprises the following steps:

[0052] S1: add the mixture material 250kg-270kg in the mixture storage tank 111 into the first reactor 130, then add the sodium methoxide 170kg-180kg into the first reactor 130, at the first predetermined temperature 110 ℃-115 Under ℃, stir intermittently until the solid sodium methoxide cannot be seen, then cool down to the second predetermined temperature of 85°C-90°C, add 1385.60kg of toluene in the toluene storage tank 112, and then cool down to the third predetermined temperature of 25°C-35°C. ℃, then dropwise add 570kg-580kg of ethyl lactate in the ethyl lactate storage tank 121, the dropping rate is 10kg / min, and the first predetermined reaction time is 0.8h-1.2h) to generate ethyl lactate sodium salt; then dropwise add The ethyl chloroacetate 415kg-425kg in the ethyl chloroacetate storage tank 122, the dropping rate is 10kg / ...

Embodiment

[0067] Add 300L of the mixture in the mixture storage tank 111 to the first reactor 130, then add 176kg of sodium methoxide to the first reactor 130, and at 110°C-115°C, stir intermittently until no longer visible. to sodium methoxide solid, then be cooled to 85 ℃-90 ℃, then add toluene 1385.60kg in the toluene storage tank 112, then be cooled to 25 ℃-35 ℃, then dropwise add the ethyl lactate storage tank 121 with 10kg / min. 578kg of ethyl lactate was reacted for 1h to generate ethyl lactate sodium salt; then 420kg of ethyl chloroacetate in the ethyl chloroacetate storage tank 122 was added dropwise at 10kg / min, and after the dropwise addition was completed, the temperature was raised to 70°C-75°C , react for 2h to generate diethyl α-methyl diglycolate, wash and distill with water after the reaction, to obtain the product diethyl α-methyl diglycolate; at 30 ℃-38 ℃, the The material of the first reaction kettle 130 was added to the washing kettle 141, and then the mixture of 750...

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Abstract

According to the furanone preparation system and method, three raw material storage tanks, namely the ethyl lactate storage tank, the ethyl chloroacetate storage tank and the sodium methoxide storage tank, are arranged in a first reaction unit, so that the added raw materials are cheap and are suitable for industrial production, the danger coefficient of the reaction is reduced, methanol is generated after the sodium methoxide reaction, the methanol is neutral, and the furanone yield is improved. The outlet of the ethyl lactate storage tank is provided with a third valve, and the outlet of the ethyl chloroacetate storage tank is provided with a fourth valve, so that when raw materials are added into the first reaction kettle, a solvent is firstly added, then sodium methoxide is added, and finally ethyl chloroacetate is added; the adding sequence of ethyl lactate and ethyl chloroacetate is controlled by controlling the opening and closing of the third valve and the fourth valve, so that the situation that the yield of the main product alpha-methyl diethyl diglycolate is reduced due to the condensation reaction of ethyl chloroacetate in the presence of sodium methoxide is avoided.

Description

technical field [0001] The invention belongs to the technical field of furanone preparation, and in particular relates to a preparation system and a preparation method of furanone. Background technique [0002] Furanone is a very important spice variety. Furanone is also known as pineapple furanone or strawberry furanone. Its chemical name is 2,5-dimethyl-4-hydroxy-3(2H)-furanone. Furanone is a A colorless or white solid with a fruity caramel aroma or a caramelized pineapple aroma, mainly used in food, beverages, cigarettes, etc. [0003] At present, the main route used in the synthesis method of furanone is to start from ethyl lactate and carry out nucleophilic substitution reaction with α-haloethyl acetate under strong alkaline conditions to generate α-methyl diglycolic acid diethyl ester, Then the compound is condensed with diethyl oxalate to close the ring, and then undergo saponification, acidification and methylation to obtain the target product. Wherein α-methyl dig...

Claims

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Application Information

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IPC IPC(8): B01J19/18B01J19/00B01J4/00C07D307/60
CPCB01J19/1818B01J19/1825B01J19/0046B01J19/0053B01J19/0066B01J4/001B01J19/0013B01J19/0006C07D307/60B01J2219/00177
Inventor 沈华张长征
Owner 宁夏万香源生物科技有限公司
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