33 results about "Methylomonas methanolica" patented technology

A process for preparing methyl aminoformate without environmental pollution includes such steps as proportionally mixing urea with methanol, reacting while supplementing the solution of urea-methanol for balancing the released ammonia-methanol vapor, purifying to obtain target product, rectifying said released vapor to obtain NH3 gas and methanol, cooling methol for recovering it, and using NH3 gas to prepare industrial ammonia water.

The invention discloses a method for semi-continuously synthesizing trimethyl borate-methanol azeotrope. The method comprises the following steps: mixing and heating boric acid and a transforming agent in a premixing tank, introducing a mixture into a stirred and heated reaction kettle, condensing gas generated in the reaction kettle, and separating; flowing a product into a mixing tank from the reaction kettle to be mixed with methanol, introducing the mixed material into a first rectifying tower, and obtaining the trimethyl borate-methanol azeotrope after tower top gas of the first rectifying tower is condensed; introducing bottom products of the first rectifying tower into a second rectifying tower; condensing tower top gas of the second rectifying tower to obtain methanol, recycling the methanol, and cooling and recycling a bottom product of the second rectifying tower. The molecular formula of the transforming agent is CxH2x+2+zOyNz, O exists in the form of hydroxyl, x is a natural number ranging from 2 to 8, y is a natural number ranging from 1 to 3, and z is a natural number not larger than 1. The method solves the problem that water generated in a traditional trimethyl borate preparation process is not easy to discharge, and digitization and automation of the process are easy to realize.

The invention relates to equipment and a method for recycling dimethyl-4-pentenoic acid methyl ester rectification residual liquid, and belongs to the technical field of 3,3-dimethyl-4-pentenoic acidmethyl ester synthesis. A condensation reaction kettle and a metering tank in the recovery equipment are connected with an inlet of an ester exchange reaction kettle through pipelines, and an outlet of the ester exchange reaction kettle is connected with an inlet of a vacuum degree adjusting tank through a condensing device; an outlet of the vacuum degree adjusting tank is connected with three branch pipes, the three branch pipes are respectively connected with the condensing device, the methanol recovery tank and the crude product tank, and an outlet of the crude product tank is connected with a feeding hole of the condensation reaction kettle and the rectification kettle. The method has the beneficial effects that the 3, 3-dimethyl-4-pentenoic acid methyl ester rectification residual liquid 3, 3-dimethyl-4-pentenoic acid isopentene ester is subjected to ester exchange reaction with methanol and sodium methoxide; by adjusting the temperature of the transesterification reaction, the vacuum degree after condensation and the reaction time, methanol, isopentenol anddimethyl-4-pentenoic acid methyl ester with high mass fraction can be collected, the recycling process is simple, and therecycling cost is reduced.

The invention relates to a production process of a medicinal raw material sodium methoxide, which comprises the following steps: proportionally adding metal sodium into a reaction kettle, slowly adding condensed methanol liquid into the reaction kettle while stirring, and continuously introducing inert gas into the reaction kettle; reacting metallic sodium with methanol liquid for 2-3 hours undernormal pressure, and thoroughly reacting to obtain a sodium methoxide mixed solution; performing heat preservation and filtration on the sodium methoxide mixed solution obtained in the step S2, obtaining filter residues and a target solution, enabling the filter residues to enter the next procedure, obtaining sodium methoxide after the target solution is subjected to negative-pressure distillationand drying, and condensing exhausted methanol gas for entering the reaction kettle again for continuous reaction. According to the method, the raw material sodium metal is prepared into molten or nanoscale powder, so that the sodium metal and methanol are fully mixed, the reaction between the sodium metal and methanol is more sufficient, the reaction speed is increased, and the reaction efficiency is improved.

The invention provides a method for preparing a method for preparing an aprepitant intermediate 2-(2-chloro-1-ethidene)hydrazide methyl formate. The method comprises the following steps: carrying out a condensation reaction between chloroacetonitrile and methyl hydrazinocarboxylate in a methanol/sodium methylate reaction solution by virtue of catalysis of glacial acetic acid, and performing after-treatment purification on the reaction solution by adopting acetone. The operation is simple, the purity of the obtained product is over 99%, and the method is high in yield and suitable for industrial production.

The invention provides an energy-saving and environment-friendly closed-loop control methanol heating stove. In the working process, a controller regulates and controls a frequency conversion fan and a throttle valve to work in a coordinated mode according to the external air pressure value detected by an atmospheric pressure sensor, and the air pressure and the air volume matched with the external air pressure value are output. The controller controls a combustor to do ignition work, the controller controls a variable-frequency electromagnetic pump to eject methyl alcohol to an igniter of the combustor, the methyl alcohol is ignited after passing through the igniter of the combustor and generates flames, and the flames enter a combustion chamber under the action of wind power. And when a flame detection sensor detects that after the methyl alcohol is ignited, the controller controls the igniter of the combustor to stop working. And the temperature of the combustion chamber and the temperature of a smoke exhaust pipe rise, and refrigerant water in a heat exchange water tank is heated. The controller regulates and controls the ignition mechanism and the oil injection mechanism to work coordinately according to the oxygen concentration, detected by a wide-range oxygen sensor, in tail smoke exhausted by the smoke exhaust pipe, and therefore it is guaranteed that high combustion efficiency of the methyl alcohol can be maintained.

The invention discloses a method for recycling cyanoacetamide in mother liquor. The method comprises the following steps of: adding primary mother liquor into a reaction kettle, and stirring; slowly rising the temperature of the reaction kettle, evaporating methanol, starting to discharge methanol when the kettle temperature achieves about 65 DEG C, cooling the methanol by using a condenser and collecting the methanol; and finishing the evaporation when the temperature inside the reaction kettle achieves 90-92 DEG C; decreasing the temperature of the reaction kettle to about 50+/-10 DEG C, subsequently adding water, toluene or heptane and the like into the reaction kettle, decreasing the temperature to 10-20 DEG C, filtering, centrifuging and drying so as to obtain a cyanoacetamide product. The method has the advantages of high recycling rate, emission reduction and pollution reduction.

The invention relates to the technical field of glyphosate production, in particular to a method and system for recovering glyphosate synthesis liquid hydrolysis tail gas. The recovery method comprises the following steps of: carrying out primary hydrolysis reaction and secondary hydrolysis reaction on acidified glyphosate synthesis liquid, and condensing the gas subjected to secondary hydrolysisreaction to obtain condensate liquid and non-condensable gas; mixing the gas generated by the primary hydrolysis reaction, the non-condensable gas and alkali liquor, and carrying out neutralization reaction; mixing the condensate liquid with the solution subjected to the neutralization reaction, adjusting the pH value to 7.5-12, carrying out gas-liquid separation on the obtained solution and the gas obtained by the neutralization reaction, and enabling the solution and the gas obtained by the gas-liquid separation to respectively enter a dividing-wall tower; discharging methylal gas from the top of the methylal side tower, and performing condensation to obtain methylal and chloromethane crude products; discharging methanol from the top of the methanol side tower; and rectifying the mixturedischarged from the tower side of the methanol side tower to obtain methanol. The recovery method is simple in process, can effectively recover byproducts, and is low in steam consumption and low incost.

The invention relates to the field of organic synthesis, and discloses a synthesis method of p-hydroxyphenylethanol, which comprises the following steps: (1) mixing methanol, sodium methoxide and a catalyst, and performing stirring; (2) adding 4-chlorophenethyl alcohol, and carrying out a heating reaction; (3) cooling to room temperature, carrying out filtering, and drying by distillation to obtain a 4-methoxyphenethyl alcohol crude product; (4) adding the crude product into a solvent, and performing stirring; (5) dropwise adding hydrobromic acid, carrying out heating reflux, and carrying outa heat preservation reaction until the reaction is finished; (6) cooling to 55-65 DEG C, slowly adding an alkaline solution, and adjusting the pH value to 6-7; and (7) cooling to 8-12 DEG C, stirringfor 0.5-1.5h, filtering the material to obtain a wet filter cake, adding a solvent, heating for dissolution, separating water, and carrying out recrystallizing, filtering, and spin-drying to obtain the final product. The product purity can reach 99% or more, the yield can reach 90% or more, and the whole synthesis process has the advantages of simple and mild reaction conditions, simple post-treatment, and low cost.

According to the furanone preparation system and method, three raw material storage tanks, namely the ethyl lactate storage tank, the ethyl chloroacetate storage tank and the sodium methoxide storage tank, are arranged in a first reaction unit, so that the added raw materials are cheap and are suitable for industrial production, the danger coefficient of the reaction is reduced, methanol is generated after the sodium methoxide reaction, the methanol is neutral, and the furanone yield is improved. The outlet of the ethyl lactate storage tank is provided with a third valve, and the outlet of the ethyl chloroacetate storage tank is provided with a fourth valve, so that when raw materials are added into the first reaction kettle, a solvent is firstly added, then sodium methoxide is added, and finally ethyl chloroacetate is added; the adding sequence of ethyl lactate and ethyl chloroacetate is controlled by controlling the opening and closing of the third valve and the fourth valve, so that the situation that the yield of the main product alpha-methyl diethyl diglycolate is reduced due to the condensation reaction of ethyl chloroacetate in the presence of sodium methoxide is avoided.

The invention provides a preparation method of 5-[(3, 4, 5-trimethoxyphenyl) methyl]-2, 4-pyrimidine diamine, and the method comprises the following steps: performing stirring and dissolving, performing heating and refluxing, performing stirring and performing suction filtration. In the stirring and dissolving step, acrylonitrile, aniline, methanol and sodium methoxide are added into a four-neck flask with a mechanical stirrer and stirred to be dissolved; the heating reflux comprises the following steps: adding a 3, 4, 5-trimethoxybenzaldehyde crude product at 50-60 DEG C within 20-30 minutes,heating to reflux and react for 2-3 hours, and carrying out TLC tracking until spots of the TMB raw material disappear. The invention has the beneficial effects that the cost is saved, the generationof solid wastes is reduced, the safety of the production process is improved, the equipment cost is reduced, and the safety risk is avoided; the yield can be increased to 93%; the method can be directly used for the next synthesis without refining, and has no influence on the purity of trimethoprim, thereby lowering the production cost and the like.