Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

The preparation method of irinotecan hydrochloride

A technology of irinotecan hydrochloride and methyl carbonate, applied in the field of preparation of antitumor drug irinotecan hydrochloride, can solve problems such as hidden dangers in production safety, increased reaction steps, environmental pollution, etc., and achieves easy transportation, reduced pollution, and post-treatment. simple effect

Active Publication Date: 2014-10-29
NANJING CHENGONG PHARM CO LTD
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above reactions, phosgene or phosgene substitutes: liquid diphosgene or solid triphosgene will inevitably be used in the reaction process. The use of this highly toxic substance has brought safety production problems. Hidden dangers, causing pollution to the environment
Method 3 does not use phosgene to activate 4-piperidinylpiperidine, but the chloroformate used in this method is still highly toxic, so the increase in reaction steps is meaningless

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • The preparation method of irinotecan hydrochloride
  • The preparation method of irinotecan hydrochloride
  • The preparation method of irinotecan hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] a) Add 4-piperidinyl piperidine (168 g, 1.00 mol), N, N-dimethylformamide (DMF) 900 mL, dimethyl carbonate ( 90 g, 1.00 mol) after the addition, control the temperature of the reaction solution at 60°C to 65°C and stir for 3 hours. After the reaction was completed, it was concentrated to dryness under reduced pressure to obtain a viscous oily substance, weighing 243g, with a yield of 100%. The intermediates in this step did not need to be purified in full to continue.

[0048] b) In a reaction flask equipped with stirring, thermometer, and condensing device, add 4-piperidinylpiperidine methyl carbonate (243 g, 1.00mol) prepared in the previous step, 1000 mL of chloroform, 7-ethyl- After the 10-hydroxycamptothecin (263 g, 0.67 mol) was stirred evenly, the temperature of the reaction solution was controlled at 45°C to 50°C and stirred for 6 hours. After the reaction was completed, 500 mL of water was added, and the chloroform layer was separated. The water layer was extra...

Embodiment 2

[0051] a) Add 4-piperidinylpiperidine (168g, 1.00 mol), acetonitrile 900mL, and dimethyl carbonate (90g, 1.00 mol) into a reaction flask equipped with stirring, thermometer, and condensing device, then control the reaction The liquid temperature was 60°C to 65°C and stirred for 3 hours. After the reaction was completed, it was concentrated to dryness under reduced pressure to obtain a viscous oily substance, weighing 240 g, with a yield of 100%. The intermediates of this step did not need to be purified in full to continue.

[0052] b) Add 4-piperidinylpiperidine methyl carbonate (240g, 1.00mol) prepared in the previous step reaction, 800 mL of dichloromethane, 7-ethyl -10-Hydroxycamptothecin (196 g, 0.50 mol) was stirred evenly, and the temperature of the reaction solution was controlled at 40°C to 45°C and stirred for 6 hours. Methane was extracted once, the combined dichloromethane layers were concentrated to dryness under reduced pressure, then 1150 mL of absolute ethanol...

Embodiment 3

[0055] a) Add 4-piperidinylpiperidine (168g, 1.00 mol), hexamethylphosphoramide 900mL, and dimethyl carbonate (90g, 1.00 mol) into a reaction flask equipped with stirring, thermometer, and condensing device After that, control the temperature of the reaction solution at 60° C. to 65° C. and stir for 3 hours. After the reaction was completed, it was concentrated to dryness under reduced pressure to obtain a viscous oily substance, weighing 240 g, with a yield of 100%. The intermediates of this step did not need to be purified in full to continue.

[0056] b) In a reaction flask equipped with stirring, thermometer, and condensing device, add 4-piperidinylpiperidine methyl carbonate (240g, 1.00mol) prepared in the previous step, petroleum ether 1000 mL, 7-ethyl- After stirring 10-hydroxycamptothecin (263 g, 0.67 mol) evenly, control the temperature of the reaction solution at 45°C to 50°C and stir for 6 hours. After the reaction, add 500mL of water to separate the petroleum ether...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of irinotecan hydrochloride. The preparation method comprises the following steps: 1, reacting 4-piperidylpiperidine with dimethyl carbonate in a dipolar aprotic solvent to generate 4-piperidylpiperidine dimethyl carbonate; 2, reacting 4-piperidylpiperidine dimethyl carbonate with 7-ethyl-10-hydroxycamptothecin in a nonpolar solvent to generate irinotecan monomers; and 3, adding water to dissolve the irinotecan monomers, adding a hydrochloric acid solution to adjust the pH value of the obtained solution to 3-4, adding acetone, crystallizing, filtering, and carrying out vacuum drying to obtain finished irinotecan hydrochloride. The preparation method which introduces carbonyl groups to the active substance dimethyl carbonate during preparation of irinotecan hydrochloride has the characteristics of safe use, convenience, small pollution, easy transportation and the like in production; the preparation method which allows use of phosgene substances to be completely avoided and pollution to the environment to be correspondingly migrated is green; and an acid binding agent is not needed by the method, and methanol which is the only byproduct is a volatile substance with a low boiling point, so post-processing is simple.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical engineering, and in particular relates to a preparation method of an antitumor drug irinotecan hydrochloride. Background technique [0002] Irinotecan Hydrochloride (CPT-11) is the most representative water-soluble camptothecin derivative jointly developed by Japan's Daiichi Seiyaku Company and Yakult Honsha Company. The trade name is Capto, and the specification is 2mL: 40mg and 5mL: 100mg. Since it was first launched in Japan in 1994, large-scale clinical studies have shown that irinotecan hydrochloride has obvious inhibitory effects on a variety of tumors such as colon cancer, small cell lung cancer, rectal cancer, leukemia, etc., and is still effective for fluorouracil-resistant cases . Therefore, irinotecan hydrochloride has attracted worldwide attention. [0003] CAS of irinotecan hydrochloride: 100286-90-6, chemical name: (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidinylpiperidine...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/22
Inventor 郭昭
Owner NANJING CHENGONG PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com