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Sunscreen composition with hollow mesoporous silica nanospheres

A technology of silicon dioxide and composition, applied in the field of preparation and use of the sunscreen composition, can solve the problems such as sunscreen actives impair the aesthetics of the composition, gritty, toxicological effect, etc.

Pending Publication Date: 2022-06-07
DOW GLOBAL TECH LLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, too high a concentration of sunscreen actives results in impairing the aesthetics of the composition (such as stickiness, greasy feel, gritty feel, whiteness, etc.) and / or undesired toxicological effects

Method used

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  • Sunscreen composition with hollow mesoporous silica nanospheres
  • Sunscreen composition with hollow mesoporous silica nanospheres
  • Sunscreen composition with hollow mesoporous silica nanospheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The inorganic hollow mesoporous silica nanospheres are characterized as follows. Two kinds of hollow mesoporous silica nanospheres with different particle size, cavity size (e.g. diameter), shell thickness and porosity have been denoted as hollow mesoporous silica nanosphere batch 1 (HMSN-1) and hollow mesoporous silica nanospheres batch 1 (HMSN-1) and hollow mesoporous silica nanospheres. Porous silica nanospheres batch 2 (HMSN-2). Both HMSN products are white powders and exhibit a regular spherical morphology.

[0041] Scanning Electron Microscopy (SEM) images were collected on a Hitachi Model S-4800 Field Emission Scanning Electron Microscope. N2 adsorption isotherms were measured at -196°C with a Micromeritics ASAP 2420 analyzer. All samples were degassed in vacuum at 180 °C for at least 6 h prior to measurement. figure 1 is the scanning electron microscope (SEM) image of the first set of hollow mesoporous silica nanospheres (HMSN-1).

[0042] Transmission elect...

Embodiment 2

[0046] Example 2 (comparison)

[0047] To determine the SPF of the comparative sunscreen compositions, sunscreen formulations Comparative Batch A, Comparative B, and Comparative Batch C were prepared with ingredients as listed in Tables 1 and 2.

[0048] Table 1

[0049]

[0050]

[0051] Table 2

[0052]

[0053]

[0054] Amounts are listed in weight percent of the composition. Although "%" is listed in the table above, it is intended to be synonymous with "wt.%".

[0055] The oil phase was prepared by mixing the oil phase components and heating to 75°C to melt the solid ingredients and form a homogeneous mixture.

[0056] The aqueous phase (excluding preservatives) was prepared by mixing the aqueous phase components together and heating to 75°C.

[0057] The oil phase is mixed into the aqueous phase with stirring. After complete mixing, the mixture was cooled to 40°C while maintaining stirring. Next, add preservatives PE 9010, and the mixture was cooled t...

Embodiment 3

[0059] To determine the SPF enhancement efficiency of hollow mesoporous silica nanospheres, HMSN-1 and HMSN-2, substantially as described in Example 1, were incorporated into sunscreen compositions (eg, sunscreen formulations) prepared with the following formulas: Ingredients listed in 3 and 4.

[0060] table 3

[0061]

[0062]

[0063] Table 4

[0064]

[0065]

[0066] Amounts are listed in weight percent of the composition. Although "%" is listed in the table above, it is intended to be synonymous with "wt.%".

[0067] The oil phase was prepared by mixing the oil phase components and heating to 75°C to melt the solid ingredients and form a homogeneous mixture.

[0068] The aqueous phase (excluding preservatives) was prepared by dispersing the listed HMSN powders in water in a separate container and homogenizing at 8000 rpm, and then mixing all aqueous phase components together and heating to 75°C.

[0069] The oil phase is mixed into the aqueous phase with ...

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Abstract

Described herein are sunscreen compositions comprising at least one sunscreen active and hollow mesoporous silica nanospheres, as well as methods of making and using the same. The sunscreen compositions described herein further include cosmetically acceptable at least one of an emollient, a wetting agent, a vitamin, a humectant, a conditioner, an oil, a silicone, a suspending agent, a surfactant, an emulsifier, a preservative, a rheology modifier, a pH adjuster, a reducing agent, an antioxidant, and / or a blowing or defoaming agent.

Description

Background technique [0001] Sunscreen compositions are generally personal care compositions designed to prevent a certain percentage of ultraviolet (UV) radiation from the sun from reaching the wearer's skin. UVA radiation (315nm–400nm) does not cause visible radiation burns (eg, sunburn), but has been shown to cause indirect DNA damage through free radical generation. UVB radiation (290nm–315nm) causes sunburn in the short term and is also associated with cancer (eg melanoma) over time. [0002] Sunscreen actives, such as physical UV blockers (eg titanium dioxide, zinc oxide) and chemical UV absorbers (eg para-aminobenzoic acid, octyl methoxycinnamate), can protect the user from UVA radiation and / or UVB radiation . The sun protection factor (SPF) rating is related to UVB blocking, and in theory, the higher the amount of sunscreen actives, such as UV filters, the higher the degree of UV protection. However, too high a concentration of sunscreen actives results in impaired a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K8/44
CPCA61Q17/04A61K8/25A61K8/0279A61K2800/412A61K2800/413A61K8/025A61K8/37
Inventor 王金秀张世玲庞孝轶陈红宇曾繁文
Owner DOW GLOBAL TECH LLC