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Valsartan tablet and preparation method thereof

A valsartan tablet and a technology for valsartan tablets, which are applied in the field of valsartan tablets and their preparation, can solve the problems of high demand for internal packaging, splintering, low moisture content of auxiliary materials, etc., so as to ensure drug quality, reduce contact area, The effect of preventing stickiness in contact with water

Pending Publication Date: 2022-06-21
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It overcomes the requirements of low environmental humidity in the production process of ordinary tablets, low moisture content of excipients, special coating requirements for coating, high demand for internal packaging, and easy splitting, discoloration, moisture absorption, and unqualified dissolution during storage.

Method used

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  • Valsartan tablet and preparation method thereof
  • Valsartan tablet and preparation method thereof
  • Valsartan tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0033] Embodiment 1-3 prescription (1000)

[0034]

[0035]

[0036] Preparation:

[0037] (1) Weigh the raw and auxiliary materials of the prescription amount

[0038] (2) Dissolve valsartan in 2L ethanol and record it as solution ①

[0039] (3) Dissolve povidone K25 in 3L of ethanol and record it as solution②

[0040] (4) Add the solution ① into the solution ②, stir evenly, evaporate the solvent, pass the granules through a 30-mesh sieve for granulation

[0041] (5) Mix the obtained granules, microcrystalline cellulose, and croscarmellose sodium evenly, then add magnesium stearate and mix evenly

[0042] (6) Tablet: hardness 7 ~ 9kg

[0043] (7) Coating: the weight gain of the coating is 3% to 5%.

[0044] Embodiment 2-3 is also prepared according to the above-mentioned preparation method

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Abstract

The invention discloses a valsartan tablet and a preparation method thereof, the tablet comprises a solid dispersion of valsartan, a filler, a disintegrating agent and a lubricant, and the solid dispersion is obtained by mixing an organic solution dissolved with valsartan and an organic solution dissolved with the solid dispersion and then removing the two organic solutions. According to the tablet obtained by the invention, the dissolvability and the dissolution rate of the indissolvable bulk drug valsartan are increased by effectively matching the tablet with auxiliary materials in a solid dispersion manner, and the accelerated experiment research shows that the film coated tablet containing valsartan prepared by the process steps is stable and controllable in quality.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, in particular to a valsartan tablet and a preparation method thereof. Background technique [0002] Hypertension is one of the most common cardiovascular diseases in the world today and the leading cause of death and disability in adults. With the progress of society and the improvement of people's living standards and the continuous acceleration of the pace of work, the number of patients with hypertension has increased significantly. The prevalence of hypertension in my country has increased significantly. According to statistics in China, the incidence of hypertension among people aged 35 to 74 in China is as high as 27%, and the number of patients is close to 130 million. , and with an annual growth rate of more than 300 million people, my country has become the country with the most serious hypertension hazards in the world. Hypertension can cause damage to the heart, brain, kidney and oth...

Claims

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Application Information

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IPC IPC(8): A61K9/30A61K31/41A61K47/32A61K9/28A61P9/12
CPCA61K9/284A61K31/41A61K9/28A61K47/32A61P9/12
Inventor 李宝杰吴方宝亓凤刘月静
Owner LUNAN PHARMA GROUP CORPORATION
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