Valsartan tablet and preparation method thereof

Abstract

The invention discloses a valsartan tablet and a preparation method thereof, the tablet comprises a solid dispersion of valsartan, a filler, a disintegrating agent and a lubricant, and the solid dispersion is obtained by mixing an organic solution dissolved with valsartan and an organic solution dissolved with the solid dispersion and then removing the two organic solutions. According to the tablet obtained by the invention, the dissolvability and the dissolution rate of the indissolvable bulk drug valsartan are increased by effectively matching the tablet with auxiliary materials in a solid dispersion manner, and the accelerated experiment research shows that the film coated tablet containing valsartan prepared by the process steps is stable and controllable in quality.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, in particular to a valsartan tablet and a preparation method thereof. Background technique [0002] Hypertension is one of the most common cardiovascular diseases in the world today and the leading cause of death and disability in adults. With the progress of society and the improvement of people's living standards and the continuous acceleration of the pace of work, the number of patients with hypertension has increased significantly. The prevalence of hypertension in my country has increased significantly. According to statistics in China, the incidence of hypertension among people aged 35 to 74 in China is as high as 27%, and the number of patients is close to 130 million. , and with an annual growth rate of more than 300 million people, my country has become the country with the most serious hypertension hazards in the world. Hypertension can cause damage to the heart, brain, kidney and oth...

AI Technical Summary

Problems solved by technology

It overcomes the requirements of low environmental humidity in the production process of ordinary tablets, low moisture content of excipients, special coating requirements for coating, high demand for internal packaging, and easy splitting, discoloration, moisture absorption, and unqualified dissolution during storage.

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