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Oil-soluble micromolecular natural biological acid antiviral and antibacterial preparation as well as preparation method and application thereof

A molecular biological acid and molecular biological technology, applied in antiviral agents, applications, antibacterial drugs, etc., can solve problems such as small doses

Pending Publication Date: 2022-06-21
GANSU YUANMEI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, formic acid, oxalic acid, lactic acid and other bio-acids with the strongest disinfection and antiseptic properties are made into oil-soluble preparations, and they are applied in small doses and used for research on the treatment of influenza. So far, no reports have been seen.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] To prepare the transdermal absorption paint of oil-oil mutual solution, according to the following ingredients:

[0105] Formic acid: 1440.0-1920.0mg

[0106] Ethyl oleate: 259.2-345.6g

[0107] Ketone essential oils: 28.8-38.4g

[0108] Ester essential oil: 28.8-38.4g

[0109] Stearyl alcohol: 40.0-80.0g

[0110] Stearic acid: 40.0-80.0g

[0111] Emulsifier (Tween-80) 70.0-90.0g

[0112] The total amount of remaining distilled water is 1200.0g

[0113] A transdermal absorption paint containing 1.2-1.6 mg of formic acid per gram is prepared.

[0114] A 60kg adult is smeared 3 times a day on the healthy skin of the chest, back and limbs, and 3.0g of the skin absorption paint is applied each time, and the skin absorption paint contains 10.08-14.4mg of formic acid. The preparation enters the blood circulation through the lymphatic system, and has a high concentration of the target drug in the respiratory tract and intestinal tract, and has a remarkable curative effect...

Embodiment 2

[0116] For the preparation of formic acid intravenous drip, according to the following ingredients:

[0117] Formic acid: 600.0-800.0mg

[0118] 2-Butanone: 120.0-160.0g

[0119] 2-Pentanone: 12.0-16.0g

[0120] 3-Heptanone: 12.0-16.0g

[0121] The rest is physiological water for injection, and the total amount of liquid is 25000.0ml; one dose is an intravenous drip containing 6.0-8.0mg formic acid per 250ml drip.

[0122] For patients who are not suitable for transdermal absorption and oral preparations. 2 times a day intravenous infusion, the daily dose of formic acid is 12.0-16.0mg. It can be used for the treatment of critically ill patients with novel coronavirus, influenza virus and other viral and bacterial infections.

Embodiment 3

[0124] To prepare formic acid oral capsule, according to the following ingredients:

[0125] Formic acid: 12000.0mg

[0126] Ethyl oleate: 1320.0g

[0127] Methyl phenylacetate: 480.0g

[0128] Gluten: 4788.0g

[0129] The total amount made: 12000 capsules, each capsule weighs 0.55g, and each capsule contains formic acid 1.0mg oral capsule.

[0130] 60kg adult, 2 times a day, 4-6 capsules each time, the daily dose of formic acid is about 8.0-12.0mg. It can be preferentially used for the treatment of rhinovirus, influenza virus, novel coronavirus and other viral and bacterial infections.

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Abstract

A micromolecular biological acid antiviral and antibacterial oil-soluble preparation contains micromolecular biological acid as an effective pharmaceutical ingredient, the micromolecular biological acid is dissolved in an oil-oil intersoluble body or an oil-water intersoluble body, and the oil-oil intersoluble body or the oil-water intersoluble body is an oil which is intersoluble with the micromolecular biological acid. The micromolecular biological acid antiviral and antibacterial oil-soluble preparation is obtained. The preparation and a pharmaceutically acceptable excipient are prepared into various dosage forms of micromolecular biological acid antiviral and antibacterial drugs. The medicine can be used as a medicine for resisting rhinoviruses, influenza viruses and other viruses and germs frequently infecting people, and can also be used as a medicine for preventing and treating novel coronavirus infection.

Description

technical field [0001] The invention relates to the field of biopharmaceuticals, and in particular provides an oil-soluble small molecule natural biological acid antiviral and antibacterial preparation and a preparation method thereof. The preparation provided by the present invention can be used as antiviral and antibacterial preventive and therapeutic drugs. In particular, it will also play an important preventive and therapeutic role in the infection of pathogens such as novel coronavirus (COVID-19), influenza virus, and rhinovirus. Background technique [0002] The virus is invisible to the naked eye, but it is very active in the earth's ecosystem. Viruses also regulate the survival of a wide range of organisms, from microbes to large mammals. The effects of viruses are not limited to living things, they also affect the Earth's climate, soils, oceans and freshwater. In 2009, scientist Dana Werner found that an average of 174 viruses reside in the human lung, of which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/194A61K9/00A61K9/48A61K9/20A61K47/14A61K47/08A61P31/12A61P31/14A61P31/16A61P31/04A41D13/11
CPCA61K31/19A61K31/194A61K9/0014A61K9/0019A61K47/14A61K47/08A61K9/4858A61K9/2013A61K9/0053A61P31/12A61P31/14A61P31/16A61P31/04A41D13/1192Y02A50/30
Inventor 王卫王邗王晓琴杨晶文
Owner GANSU YUANMEI PHARM CO LTD