Anti-saccharification and anti-oxidation composition containing nicotinamide mononucleotide and application of anti-saccharification and anti-oxidation composition

A technology of composition and ceramide, which is applied in the direction of medical preparations containing active ingredients, drug combinations, amide active ingredients, etc., can solve the problem of unsatisfactory use of anti-glycation and anti-oxidation products, few anti-glycation and anti-oxidation products, Low absorption rate of active ingredients and other issues, to achieve large-scale production, promote the formation of GSH-Px, and reduce production costs

Pending Publication Date: 2022-07-01
曙光生命科技株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are not many anti-glycation and anti-oxidation products at present, and the effect of many anti-glycation and anti-oxidation products on the market is not ideal, and there are problems such as low absorption rate of some active ingredients by t

Method used

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  • Anti-saccharification and anti-oxidation composition containing nicotinamide mononucleotide and application of anti-saccharification and anti-oxidation composition
  • Anti-saccharification and anti-oxidation composition containing nicotinamide mononucleotide and application of anti-saccharification and anti-oxidation composition

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Embodiment 1 A kind of preparation of pill containing nicotinamide mononucleotide

[0031]Raw material (composition 1): Nicotinamide mononucleotide (NMN) 70.1g, fish collagen peptide 8g, anserine 6.3g, ceramide 0.8g, astaxanthin 0.8g, grape seed extract 0.8g, cherry blossom extract 0.8g, pomegranate fruit extract 0.8g, olive leaf extract 0.8g, red wine essence powder 0.8g, green tea extract 0.8g, vitamin B2 0.6g, vitamin B6 hydrochloride 0.6g, vitamin C 6g.

[0032] Excipients: use conventional excipients in the field, preferably 0.8g tomato pigment, maltitol, microcrystalline cellulose, hydroxypropyl cellulose, silicon dioxide particles and magnesium stearate totaling 130.12g.

[0033] The dried raw materials and auxiliary materials are proportioned and weighed, the fine powder of the drug is obtained by grinding and sieving, and then the wet pill is made by the conventional process, which is then dried and processed into dry pills. The dry pills are polished and coate...

Example Embodiment

[0040] The preparation of a kind of pill containing nicotinamide mononucleotide of embodiment 2

[0041] Raw material (composition 2): nicotinamide mononucleotide (NMN) 66.7g, fish collagen peptide 10g, anserine 6.7g, ceramide 0.7g, astaxanthin 0.7g, grape seed extract 0.7g, cherry blossom extract 0.7g, pomegranate fruit extract 0.7g, olive leaf extract 0.7g, red wine essence powder 0.7g, green tea extract 0.7g, vitamin B2 0.4g, vitamin B6 hydrochloride 0.4g, vitamin C 8g.

[0042] Excipients: Use conventional excipients in the field, preferably tomato pigment 0.7g, maltitol, microcrystalline cellulose, hydroxypropyl cellulose, silicon dioxide particles and magnesium stearate in a total of 130.12g.

[0043] The dried raw materials and auxiliary materials are proportioned and weighed, the fine powder of the drug is obtained by grinding and sieving, and then the wet pill is made by the conventional process, which is then dried and processed into dry pills. The dry pills are poli...

Example Embodiment

[0050] Example 3

[0051] Adjust the amount of nicotinamide mononucleotide (NMN) to 60g, 50g and 30g to obtain compositions 3 to 5; other conditions and preparation methods are the same as in Example 1, to obtain experimental products 3, 4 and 5.

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PUM

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Abstract

The invention discloses an anti-saccharification and anti-oxidation composition containing nicotinamide mononucleotide and application of the anti-saccharification and anti-oxidation composition. The composition is prepared from the following components in parts by weight: 50 to 70.1 parts of NMN, 8 to 12 parts of collagen, 6.3 to 7.5 parts of carnosine and 0.7 to 0.8 part of ceramide. The composition can significantly reduce generation of AGEs and MDA in cells, promote generation of GSH-Px at the same time, and slow down skin aging; the NMN is compounded with each active substance, so that the cost of the preparation can be reduced, and the absorption rate of the active substance can be improved by oral preparation.

Description

technical field [0001] The invention relates to the technical field of medicine and health care, in particular to an anti-glycation and antioxidant composition containing nicotinamide mononucleotide and its application. Background technique [0002] Current research shows that advanced glycation end products (AGEs) can accelerate the aging of the human body and cause various chronic degenerative diseases, such as diabetes, Alzheimer's disease, atherosclerosis and other diseases. Advanced glycation end products are the end products of free amino groups and reducing sugars on proteins and other molecules through Maillard (non-enzymatic glycation) reactions. [0003] The Maillard reaction is mainly divided into three stages: in the first stage, the carbonyl group in the reducing sugar (such as glucose, fructose) undergoes a nucleophilic addition reaction with a free amino group to rapidly generate a class of unstable imine compounds. Schiff base. The formation of Schiff bases...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61P39/06A61K31/706A61K31/164A61K38/05A61K36/87A61K31/122A61K31/525A61K31/4415A61K31/375
CPCA61K31/706A61K38/39A61K31/164A61K38/05A61K31/122A61K36/87A61K36/185A61K36/32A61K36/82A61K36/73A61K31/525A61K31/4415A61K31/375A61K9/0053A61P39/06A61K2300/00
Inventor 郭婉琳
Owner 曙光生命科技株式会社
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