Binuclear cadmium complex with anticancer activity as well as preparation method and application thereof

A technology for cadmium complexes and anticancer activity, applied in the field of binuclear cadmium complexes and their preparation, can solve the problem that biological activity research is rare, and achieve significant antitumor cell activity, good luminescence performance, and good π-conjugation flat effect
CN114685536AActive Publication Date: 2022-07-01ZHONGSHAN POLYTECHNIC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHONGSHAN POLYTECHNIC
Publication Date
2022-07-01

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Abstract

The invention discloses a binuclear cadmium complex with anticancer activity as well as a preparation method and application thereof. The binuclear cadmium complex is an infinite network structure material formed by connecting cadmium salt and an organic ligand in a coordination bond manner, the binuclear cadmium complex is di-[4-fluoro-N '-(2-hydroxyl-3-methoxybenzylidene) benzoyl hydrazine], or di-[N'-(2-hydroxyl-3-methoxybenzylidene)-4-(1, 2, 2-triphenylvinyl) benzoyl hydrazine], or di-[N '-(2-hydroxyl-3-methoxybenzylidene)-4-(1, 2, 2-triphenylvinyl) benzoyl hydrazine], or di-[N'-(2-hydroxyl-3-methoxybenzylidene)-4-(1, 2, 2-triphenylvinyl) benzoyl hydrazine]. The binuclear cadmium complex disclosed by the invention takes a binuclear planar cadmium unit as a metal ligand, is assembled into a metal organic framework with a stable planar structure, has relatively strong tumor cell apoptosis inducing capability on human breast cancer cells and human lung cancer cells, and also has remarkable tumor cell resisting activity. Therefore, the binuclear cadmium complex provided by the invention is a promising material for developing novel anti-tumor drugs, and has a relatively high application value in developing the anti-tumor drugs.
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Description

technical field

[0001] The invention belongs to the technical field of metal-organic framework materials, and in particular relates to a dual-nuclear cadmium complex with anticancer activity and a preparation method and application thereof. Background technique

[0002] Metal complexes have been extensively studied because of their tunable structures and positive charges, which are very favorable for their interaction with the phosphate backbone of DNA. These research works have broadened the knowledge field of the biochemistry of the interaction between metal complexes and DNA to a certain extent, but such research is currently mainly focused on mononuclear metal complexes, as opposed to planar binuclear metal complexes. Objects have less work. Therefore, designing and synthesizing planar binuclear metal complexes targeting DNA can provide another broad space for the development of new anti-tumor and anti-cancer drugs.

[0003] Acylhydrazones are a class of Schiff base or...

Claims

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