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Application of model constructed based on necroptosis-related gene combination in preparation of product for predicting prognosis of low-grade glioma

A technology of necroptosis and gene combination, which is applied in the application field of preparing products for predicting the prognosis of low-grade glioma, and achieves the effect of good and high predictive performance

Pending Publication Date: 2022-07-12
郑州源创基因科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

YIPF2 promotes apoptosis by enhancing the recycling of TNFRSF10B to the plasma membrane of NSCLC cells, however, the application of these genes in LGG has not been reported

Method used

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  • Application of model constructed based on necroptosis-related gene combination in preparation of product for predicting prognosis of low-grade glioma
  • Application of model constructed based on necroptosis-related gene combination in preparation of product for predicting prognosis of low-grade glioma
  • Application of model constructed based on necroptosis-related gene combination in preparation of product for predicting prognosis of low-grade glioma

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Experimental program
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Effect test

Embodiment 1

[0026] Screening of necroptosis-related genes and model construction for prognosis prediction of LGG

[0027] (1) Acquisition of patient information: The low-grade glioma RNA sequencing data (RNA-seq) and corresponding clinical data, including age, sex, stage, overall survival time and survival status, were downloaded from the CancerGenomeAtlas (TCGA) website. To reduce statistical bias, patients with no survival information or with a survival time of less than 30 days were excluded from further evaluation, and after screening, 529 LGG patients in the TCGA database were finally included in the analysis.

[0028] (2) Screening prognosis-related necroptosis-related genes as prognostic biomarkers or constructing prognostic models: necroptosis-related genes were collected from KEGG, and 161 necroptosis-related genes were retrieved according to the available mRNA expression data of LGG in TCGA. Apoptosis-related genes. By comparing tumor tissue and normal tissue, 12 genes were up-...

Embodiment 2

[0039] 4. The guiding significance of prognostic model for prognostic treatment

[0040] IC50 values ​​for several high- and low-risk drugs (various antineoplastic drugs recommended for the treatment of low-grade glioma: bortezomib, cyclopamine, The sensitivities of satinib, rapamycin, and roskovetine were compared between groups, and the results were as follows Figure 8 , bortezomib (P Figure 8 A-E) Sensitive. In addition, we used Tumor Immune Dysfunction and Rejection (TIDE) to assess the potential clinical efficacy of immunotherapy between the two groups. We calculated TIDE scores for each patient, ranging from -0.5-1.23, with higher TIDE scores in patients in the high-risk group than in the low-risk group ( Figure 8 F). Since a higher TIDE score indicates a higher possibility of anti-tumor immune evasion and less likely to benefit from immune checkpoint blockade therapy, patients in the high-risk group may have immune evasion, which also explains the high-risk group. ...

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Abstract

The invention discloses application of a model constructed based on necroptosis related gene combination in preparation of a product for predicting prognosis of low-grade glioma, necroptosis related genes: BID, H2AFY2, MAPK9 and TNFRSF10B are adopted as detection targets, and the constructed model is good in prediction performance; the construction of a column diagram combining a necroptosis-related gene risk assessment model and clinical factors has higher prediction performance on the survival rate; the difference comparison of high risk and low risk in the model in the aspect of immune infiltration and the medication guidance of the prognosis model on the prognosis treatment are expected to use the model constructed based on the necroptosis related gene in the clinical prediction of the prognosis and immunotherapy response of the LGG patient.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to the application of a model constructed based on a combination of necroptosis-related genes in preparing a product for predicting the prognosis of low-grade glioma. Background technique [0002] Gliomas are the most common primary central nervous system malignancies, accounting for about 80% of all central nervous system malignancies, according to the American Brain Tumor Registry. The WHO classification of the central nervous system divides gliomas into whoI-IV grades, with grades I and II as low grades, and grades III and IV as high grades. Although low-grade glioma (LGG) accounts for only 20%, the choice of treatment is affected by many factors. Low-grade gliomas have malignant biological characteristics such as aggressive growth and resistance to radiotherapy and chemotherapy, and have a tendency to develop into high-grade gliomas. With the gradual deepening of its resea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11G16B5/00G16B20/30
CPCC12Q1/6886G16B5/00G16B20/30C12Q2600/118C12Q2600/158
Inventor 徐茜赵辉郭玉刚高萧芳孙宪凯
Owner 郑州源创基因科技有限公司
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