Application of polygonatum odoratum polysaccharide in preparation of medicine for treating asthma

A kind of Polysaccharide Polysaccharide, medicine technology, applied in medicine application field

Active Publication Date: 2022-07-22
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no evidence to prove that simple intestinal flora regulation can treat asthma, so even if probiotics are used clinically, they are only used as adjuvant therapy

Method used

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  • Application of polygonatum odoratum polysaccharide in preparation of medicine for treating asthma
  • Application of polygonatum odoratum polysaccharide in preparation of medicine for treating asthma
  • Application of polygonatum odoratum polysaccharide in preparation of medicine for treating asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The embodiment of the present invention provides a preparation method of Polysaccharide Polysaccharide:

[0042] Weigh 2kg of Yuzhu decoction pieces, crush them with a crusher, add distilled water at a liquid-material ratio of 10:1, stir evenly with a glass rod, and soak them for 1 hour, so that the medicine and water are fully mixed and soaked, heated to a slight boil, and the timing is started. 2h. After the medicinal liquid was cooled to room temperature, filter the medicinal residues with 9 layers of gauze. The filtered medicinal residues were extracted for the second time at a liquid-to-material ratio of 8:1. The extraction time was 2 hours. The two filtrates were combined and stored at 4°C. The final concentration of ethanol was adjusted to 80% with 95% ethanol, and the alcohol was allowed to settle overnight at 4°C. The ethanol in the precipitate was completely spun out with a rotary evaporator, and 254 g of Polysaccharide Polysaccharide was obtained after freez...

Embodiment 2

[0044] The embodiment of the present invention provides a preparation method of Polysaccharide Polysaccharide:

[0045] Weigh 2kg of Yuzhu decoction pieces, crush them with a crusher, add distilled water at a liquid-material ratio of 9:1, stir evenly with a glass rod, and soak them for 1 hour, so that the medicine and water are fully mixed and soaked, heated to a slight boil, and the timing is started. 2h. After the medicinal liquid was cooled to room temperature, the medicinal residue was filtered with 9 layers of gauze. The filtered medicinal residue was extracted for the second time at a liquid-to-material ratio of 7:1. The extraction time was 2 hours. The two filtrates were combined and stored at 4°C. Use 95% ethanol to adjust the final concentration of ethanol to 75%, and let stand at 4°C for alcohol precipitation overnight. The ethanol in the precipitate was completely spun out with a rotary evaporator, and 246 g of Polysaccharide Polysaccharide was obtained after freez...

Embodiment 3

[0047] The embodiment of the present invention provides a preparation method of Polysaccharide Polysaccharide:

[0048] Weigh 2kg of Yuzhu decoction pieces, crush them with a crusher, add distilled water at a liquid-to-material ratio of 11:1, stir evenly with a glass rod, and soak them for 1 hour, so that the medicine and water are fully mixed and soaked, heated to a slight boil, and the timing is started. 2h. After the medicinal liquid was cooled to room temperature, filter the medicinal residues with 9 layers of gauze. The filtered medicinal residues were extracted for the second time at a liquid-to-material ratio of 9:1. The extraction time was 2 hours. The two filtrates were combined and stored at 4°C. Use 95% ethanol to adjust the final concentration of ethanol to 85%, and let stand at 4°C for alcohol precipitation overnight. The ethanol in the precipitate was completely spun out with a rotary evaporator, and 249 g of Polysaccharide Polysaccharide was obtained after free...

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Abstract

The invention belongs to the technical field of medicines for treating asthma, and particularly relates to application of polygonatum odoratum polysaccharide in preparation of medicines for treating asthma. Experimental research finds that the polygonatum odoratum polysaccharide can improve release of allergic asthma related cell factors in an airway, reduce the number of eosinophilic granulocytes, reduce serum total IgE, improve allergy conditions and improve pathological conditions such as lung inflammatory infiltration, goblet cell metaplasia and pulmonary parenchyma of asthma mice. Therefore, the polygonatum odoratum polysaccharide can be used for preparing the medicine for treating asthma.

Description

technical field [0001] The invention belongs to the technical field of asthma treatment medicines, and particularly relates to the application of polysaccharides of Polygonatum japonica in the preparation of medicines for the treatment of asthma. Background technique [0002] Bronchial asthma (hereinafter referred to as asthma) has a high incidence worldwide. Asthma in children is accompanied by recurrent episodes of wheezing, coughing, shortness of breath, chest tightness and other clinical manifestations. It has a variety of different clinical and pathophysiological features, mainly characterized by chronic airway inflammation and airway hyperresponsiveness. [0003] Asthma is closely related to immune regulation. Individual susceptibility, viral infection, allergen exposure and other factors lead to immune imbalance triggering asthma, and immune cells play a key role in the development of asthma. Improving immunity can help reduce diseases caused by viruses and allergen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K36/8969A61P11/06A61P37/08A61K125/00
CPCA61K31/715A61K36/8969A61P11/06A61P37/08Y02A50/30
Inventor 高秀梅赵鑫崔天怡李澜付志飞吕彬杨文志刘佳蕊
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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