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Electrode, sensor and instant detection system for detecting drugs containing phosphonic acid groups

A detection system and drug technology, applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of poor selectivity and difficulty in meeting on-site reduction detection, and achieve the effect of improving selectivity and sensitivity

Pending Publication Date: 2022-07-29
湖南千金湘江药业股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the detection of drugs containing phosphonic acid groups in biological samples such as serum and urine by traditional modified electrodes is easily interfered by biological matrices and has poor selectivity.
At present, most electrochemical sensors are only suitable for laboratory detection, and it is difficult to meet the requirements of on-site reduction detection.

Method used

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  • Electrode, sensor and instant detection system for detecting drugs containing phosphonic acid groups
  • Electrode, sensor and instant detection system for detecting drugs containing phosphonic acid groups

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of Molecularly Imprinted Polypyrrole Film / Black Phosphorus-Modified Screen-Printed Electrode:

[0036] (1) Tenofovir is used as template molecule and pyrrole is used as functional monomer. The molar ratio of tenofovir and pyrrole was 1:2.

[0037] (2) Electrochemical polymerization of the black phosphorus-modified screen-printed electrode was carried out in the solution of tenofovir and pyrrole, the scanning potential was -0.2 ~ 0.8 V, and the number of scanning cycles was 10. After the reaction, the electrode was washed with a solvent composed of methanol and 1 mol / L sodium hydroxide solution according to a volume ratio of 1:1 for 20 min, and the template was removed to obtain a molecularly imprinted polypyrrole film / black phosphorus modified screen-printed electrode.

Embodiment 2

[0039] The molecularly imprinted polypyrrole film / black phosphorus-modified screen-printed electrode, screen-printed carbon electrode, and Ag / AgCl-modified screen-printed carbon electrode prepared in Example 1 were used to form a three-electrode system to construct a molecularly imprinted electrochemical sensor.

Embodiment 3

[0041] Construction of a point-of-care detection device for drugs containing phosphonic acid groups:

[0042] Portable electrochemical equipment, including MSP430 microprocessor, I / V conversion circuit, filter amplifying circuit; the microprocessor is respectively connected with A / D analog-to-digital conversion circuit and D / A digital-to-analog conversion circuit.

[0043] The portable electrochemical device is electrically connected to the molecularly imprinted sensor constructed in Example 2, the scanning voltage is provided for the sensor through the D / A digital-to-analog conversion circuit, and the electrochemical experiments of the sensor are collected by using the I / V conversion circuit and the A / D analog-to-digital conversion circuit The data is transmitted to the smartphone application terminal by means of wireless communication through the microprocessor.

[0044] The smart phone includes a wireless communication module, a data processing module and a data storage modul...

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Abstract

The invention belongs to the technical field of rapid detection, and discloses an electrode, a sensor and a real-time detection system for detecting drugs containing phosphonic acid groups. The electrode is a molecularly imprinted polypyrrole film / black phosphorus modified screen-printed electrode, and is prepared by the following steps: carrying out electrochemical polymerization reaction on the black phosphorus modified screen-printed electrode in a solution which takes a phosphonic acid group-containing drug as a template molecule and pyrrole as a functional monomer, and eluting with a solvent to remove the template after the reaction is completed. The intelligent electrochemical detection system for instantly detecting the medicine containing the phosphonic acid group is constructed by combining a molecularly imprinted polypyrrole / black phosphorus composite material with a specific recognition function with portable electrochemical equipment and a smart phone. The detection system has the outstanding advantages of low cost, miniaturization, instant detection and the like, and in-situ real-time monitoring of drugs containing phosphonic acid groups in biological samples such as serum and urine is realized.

Description

technical field [0001] The invention belongs to the technical field of rapid detection, and particularly relates to an electrode, a sensor and a detection system for detecting a phosphonic acid group-containing drug. Background technique [0002] Drugs containing phosphonic acid groups such as tenofovir, polysaccharide, and phosphoformate (sodium) play an important role in the treatment of AIDS and herpes caused by viruses. At the same time, these phosphonic acid group-containing drugs are less toxic and can also be used for the treatment of many other diseases. Quantitative detection of drugs containing phosphonic acid groups such as tenofovir, polysaccharide, and phosphoformate (sodium) plays a very important role in the diagnosis and treatment of related diseases. Immediate detection of the content of phosphonic acid group-containing drugs in serum can help doctors and patients to better understand the physiological and pathological effects of phosphonic acid group-conta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/416
CPCG01N27/3275G01N27/416
Inventor 姚亮元贺全国李广利刘军袁红波刘瑞环肖静芸魏艳萍
Owner 湖南千金湘江药业股份有限公司
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