Slow-release antibacterial gel for treating female leukoplakia vulvae and preparation method thereof

Abstract

The invention provides slow-release antibacterial gel for treating female leukoplakia vulvae and a preparation method of the slow-release antibacterial gel, and relates to the technical field of medical antibacterial gel processing. The sustained-release antibacterial gel is formed by compounding a hydrogel material and drug-loaded microspheres, the hydrogel material is obtained by mixing oxidation-modified hydroxypropyl carboxymethyl cellulose and modified chitosan, and the drug-loaded microspheres are prepared by loading effective drug components on carboxymethyl chitosan. The defects in the prior art are overcome, the gel microbeads are mixed with effective medicine components and then are wrapped with hydrogel to prepare a medicine release system, the purpose of medicine slow release is effectively achieved, toxic and side effects are reduced while the long-term curative effect of the medicine is guaranteed, the physiological environment of the affected part is protected, and the use comfort is improved.

Description

technical field [0001] The invention relates to the technical field of medical antibacterial gel processing, in particular to a slow-release antibacterial gel for treating leukoplakia and a preparation method thereof. Background technique [0002] Vulvar dystrophy, also known as vulvar white lesions, vulvar intraepithelial non-tumor-like lesions, vulvar leukoplakia, etc., is a chronic and common disease characterized by degeneration and pigment changes in female vulvar skin and mucous membranes. , and the pathogenesis of vulvar dystrophy is still unclear. [0003] The current clinical treatment methods for leukoplakia include drug therapy, ultrasound therapy, microwave therapy, hyperbaric oxygen therapy, laser therapy, warm acupuncture and moxibustion therapy, and surgical therapy. Considering the comfort, convenience and safety of treatment, most patients will choose drug treatment. Generally, the drugs for leukoplakia include glucocorticoids, immunomodulators, anti-tumor ...

AI Technical Summary

Problems solved by technology

[0004] Since the lotion mostly contacts the affected area with the drug during cleaning, and the drug stays for a short time, high-concentration drugs are often used to directly achieve the purpose of administration and achieve the purpose of bactericidal treatment, and the general method of use is multiple times a day. It is cumbersome, and the direct application of ointment is relatively convenient. However, due to the characteristics of the ointment and the characteristics of the patient's physiological structure, the general ointment will damage the reproductive tract environment and the secretion function of the mucosa itself after long-term application, resulting in reproductive failure. The decline of the local immunity of the tract, and trauma to the human body, destroys the secretion function of the cervix, causes the vaginal resistance to decrease, and seriously affects the sexual life and reproductive health

[0005] In view of the above problems, most of the materials such as hydrogel are used to treat the affected area with effective drug ingredients at this stage. Among them, hydrogel has good biocompatibility, biodegradability and low toxicity. However, when this kind of material is used, the drug The release system is to release the active ingredients directly and quickly to treat the affected area. However, many drugs will produce large side effects after a period of time, and will cause patients to develop drug resistance, reduce the therapeutic effect of the drug, and bring serious clinical problems. Treatment brings some trouble

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