Pharmaceutical capsule compositions containing loratadine and pseudoephedrine
A technique of pseudoephedrine and composition, applied in the field of oral medicine capsule composition, can solve problems such as poor wettability, unsatisfactory pseudoephedrine delivery mode and the like
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Embodiment 1
[0034] Example 1: Preparation of Quick Release Pills Containing Loratadine and Pseudoephedrine Sulfate
[0035] A binder solution was prepared by dissolving 5.0 g of polyvinylpyrrolidone in 120 g of water. 25g loratadine, 180g pseudoephedrine sulfate, 25g microcrystalline cellulose, 75g low-substituted hydroxypropyl cellulose, 75g polyvinylpolypyrrolidone and 1.5g colloidal silicon dioxide were mixed and sieved by a 20-mesh sieve. Give mixed powder. While spraying the binder solution prepared above onto 250 g of sugar seeds in a centrifugal granulator, the mixed powder was dusted onto the sugar seeds in a centrifugal granulator to provide pellets. (Turntable speed: 140~200rpm, adhesive solution spraying speed: 2~20ml / min, air injection pressure: 1~2kg / cm 2 , air injection volume: 5 ~ 300L / min, powder spraying speed: 5 ~ 30g / min)
Embodiment 2 and 3
[0036] Examples 2 and 3: Preparation of Rapid Release Pellets Containing Loratadine and Pseudoephedrine Sulfate
[0037] The procedure of Example 1 was repeated except that the amounts of the components were changed as shown in Table 1 to obtain additional samples of rapid release pellets containing pseudoephedrine sulfate and loratadine.
[0038] Example 2
Embodiment 4
[0039] Embodiment 4: the preparation of the core pill containing pseudoephedrine sulfate
[0040] A binder solution was prepared by dissolving 20 g of hydroxypropyl cellulose in 480 g of water. 1200 g of pseudoephedrine sulfate and 3 g of colloidal silicon dioxide were mixed and sieved through a 20-mesh sieve to give a mixed powder. While spraying the binder solution prepared above onto 600 g of sugar seeds in the centrifugal granulator, the mixed powder was dusted on the sugar seeds in the centrifugal granulator to provide pellets. The pellets obtained were dried at 50°C until its water content was less than 2% as determined by a Kett-moisture analyzer to give core pellets containing pseudoephedrine sulfate.
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