Wound spray for treating burn

Abstract

A wound spray for treating burn is prepared from glaucousback threewingnut stem, air-plant herb and propolis through immersion extracting to obtain liquid extracts and proportionally mixing. Its advantages are convenient application, low cost, and short course of treatment.

Description

technical field [0001] The invention belongs to an external medicine for treating burns. Background technique [0002] At present, the external wound medicines used in the clinical treatment of burns include: sulfadiazine silver (SD-Ag) cold cream, Zinning burn spray, sulfamidone cream, sulfadiazine zinc cream, silver zinc cream, sulfadiazine silver-cerium cream , Bactobang ointment, love therapy ointment, trypsin ointment, clotrimazole cream, iodophor cream, gentamicin cold cream, medical AV wound cream and so on. Though these medicines have certain effect to treatment burn, also there are many deficiencies respectively. For example, the deficiency of sulfadiazine silver (SD-Ag) cold cream is: 1, the penetration ability to necrotic tissue is relatively poor, can not reach effective antibacterial concentration in eschar deep layer and necrotic tissue and living tissue interface; The combination of epidermal keratinocyte DNA inhibits the prolifer...

AI Technical Summary

Problems solved by technology

For example, the deficiency of sulfadiazine silver (SD-Ag) cold cream is: 1, the penetration ability to necrotic tissue is relatively poor, can not reach effective antibacterial concentration in eschar deep layer and necrotic tissue and living tissue interface; The combination of epidermal keratinocyte DNA inhibits the proliferation of epidermal keratinocytes and delays wound healing; 3. The dry scab formed on the wound surface is achieved by sacrificing a large amount of vital tissue, and the dry scab has a certain space-occupying property after formation, and is prone to subcrustation Empyema restricts and delays the growth of new epithelium, delays wound healing, and the healing wound may fester again. Undoubtedly, this secondary injury will inevitably deepen the depth of the wound, resulting in scar healing

The disadvantages of Chining Burn Spray are: 1. The liquid medicine is highly acidic, and the wound pain is aggravated when the medicine is used; 2. Some patients have pus under the scab after the scab on the wound; It hinders the epithelialization of the wound, and the scab needs to be removed manually; 4. The patient feels pain when the scab dries and shrinks

The deficiencies of sulfamidone cream are: 1. Large-scale application of sulfamidone can cause metabolic acidosis, because it has a strong inhibitory effect on carbonic anhydrase, which increases urine output, affects the function of renal tubules to discharge acid and maintain alkali, and a large amount of urine Sodium bicarbonate is discharged, and chloride ion retention leads to hyperchloric metabolic acidosis. Therefore, the area of ​​medication should not exceed 60% of the body surface area, and the total amount of daily medication should not exceed 10% of cream 500g; 2. Although it can inhibit the proliferation of bacteria under the scab, It can also inhibit the growth of epithelial cells, which can delay the separation of eschar, which is not conducive to wound healing; 3. The incidence of pulmonary complications is high after long-term use, which can cause hyaline membrane changes; Large, persistent pain after medication, patients can tolerate it after 5-7 days, and some patients have allergies; 5. Once the wound is infected, it is necessary to replace the drug that does not hinder wound healing in time

The disadvantage of sulfadiazine silver-cerium cream is that the separation of necrotic tissue is delayed, which affects wound healing

The disadvantages of Bactobang ointment are: 1. Use with caution in patients with moderate renal impairment; 2. The maximum medication area should not exceed 20% of the body surface area to avoid renal impairment

The disadvantages of Atherapeutic ointment are: 1. Collagenase can soften and liquefy the eschar, and cannot remove the liquefied matter, which creates an environment conducive to the growth and reproduction of bacteria, which aggravates infection and is not suitable for use on wounds with a lot of necrotic tissue; 2. , no anti-infection and promote wound healing

The deficiency of medical AV wound face cream is: 1, identical with sulfadiazine silver (SD-Ag) cold cream

[0003] The above-mentioned external medicines for burn wounds also have the following shortcomings: 1. The pharmacological effects are limited and independent, and there is no one kind of medicine that can treat the whole process to healing; 3. All cream-type preparations must be changed every day, 2 to 4 times a day, which not only increases the labor intensity of medical staff, but also increases the pain of patients during dressing changes. Applying ointment or cream is not conducive to observing changes in the wound surface, and is easy to stain 4. It does not have the function of preventing body fluid exudation from burn wounds and wound debridement and drainage

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