Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug

A technology of block copolymers and hydrophilic polymers, which is applied in the field of transporting anionic bioactive reagents and polymer micellar drug carriers, and can solve the problems of reducing drug stability and other issues
CN1220717CInactive Publication Date: 2005-09-28SAMYANG HLDG CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SAMYANG HLDG CORP
Publication Date
2005-09-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a cationic group-containing amphiphilic block copolymer that is biocompatible and biodegradable, and when used as a drug carrier for an anionic drug, provides several advantages, such as increased blood concentration and improved stability of the drug.
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Description

technical field

[0001] The present invention relates to positively charged drug carriers which form complexes with negatively charged drugs. More specifically, the present invention relates to positively charged polymer micellar drug carriers comprising A-B block type copolymers, wherein A is a hydrophilic polymer block, and B is a hydrophobic biodegradable polymer block, and wherein one end of the hydrophobic polymer block (B) is covalently bonded to a cationic group. The positively charged biodegradable block copolymer of the present invention forms complexes with negatively charged drugs by means of electrostatic interactions. The cationic copolymers of the present invention are useful for drug delivery, and in particular for the delivery of anionic bioactive agents. Background of the invention

[0002] Biodegradable polymers are attracting attention as drug delivery systems. R. Langer, New Methods of Drug delivery, 249 Science 1527-1533 (1990); B. Jeong et al., Biodeg...

Claims

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