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Biological degradable PES graft polyphosphonitrile copolymer and its preparation

A technology of degradability and copolymer, which is applied in the field of biodegradable polyester grafted polyphosphazene copolymer and its preparation, can solve the problems of slow degradation rate and slow degradation rate of graft copolymer, and achieve the reduction of aseptic Sexual inflammation, excellent biodegradability, effect of improving hydrophilicity and biodegradation speed

Inactive Publication Date: 2006-05-03
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strong hydrophobicity and slow degradation rate of polycaprolactone, as well as the non-degradability of methyl and phenyl groups, the degradation rate of the above-mentioned graft copolymer is extremely slow, so it is not suitable as a tissue engineering cell scaffold material or Drug Controlled Release Carrier Materials

Method used

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  • Biological degradable PES graft polyphosphonitrile copolymer and its preparation
  • Biological degradable PES graft polyphosphonitrile copolymer and its preparation
  • Biological degradable PES graft polyphosphonitrile copolymer and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Dissolve 0.58 g of linear polydichlorophosphazene (the degree of polymerization is about 450, and the molecular weight is 50,000 to 60,000) obtained by ring-opening polymerization of hexachlorophosphazene ring trimer in 10 ml of dry tetrahydrofuran, and then slowly pour into it Add dropwise 50 ml of a tetrahydrofuran solution containing 7.0 g of sodium methoxypolyethylene glycol (taking polyether with a molecular weight of 350 as an example), and reflux at 60° C. for 24 hours. The generated sodium chloride was removed by filtration, and then the tetrahydrofuran solution was precipitated with n-hexane to obtain a methoxypolyethylene glycol-substituted polyphosphazene (PMEP-1) elastomer.

[0043] Dissolve 7.45 g of the above-mentioned elastomer in 50 ml of chloroform, then add 2.0 g of iodotrimethylsilane to it, heat up to 30-35° C. and react for 3 days, then distill off the solvent under reduced pressure to dryness. Then the resultant was dissolved in tetrahydrofuran, 5:...

Embodiment 2

[0046] Dissolve 1.16 g of linear polydichlorophosphazene (polymerization degree about 1000, molecular weight about 100,000) obtained by ring-opening polymerization of hexachlorophosphazene ring trimer in 20 ml of dry tetrahydrofuran, and then slowly drop it Add 50 ml of tetrahydrofuran solution containing 4.0 g of sodium methoxyethoxide, and reflux at 60°C for 24 hours. The generated sodium chloride was removed by filtration, and then the tetrahydrofuran solution was precipitated with n-hexane to obtain a methoxyethoxy-substituted polyphosphazene (PMEP-2) elastomer.

[0047] Dissolve 3.90 g of the above-mentioned elastomer in 40 ml of dichloromethane, then add 4.0 g of iodotrimethylsilane to it, heat up to 30-35° C. and react for 3 days, then distill off the solvent under reduced pressure to dryness. Then dissolve the resultant in dioxane, add 3:1 (tetrahydrofuran / water, v / v) water to it, hydrolyze at room temperature for 1 hour, and remove the solvent and water to obtain ethy...

Embodiment 3

[0050] Dissolve PMEP-2 (3.90g) prepared according to Example 2 in 40ml of chloroform, then add 2.40g of iodotrimethylsilane to it, heat up to 30-35°C and react for 2 days, evaporate the solvent under reduced pressure to dryness . Then the resultant was dissolved in tetrahydrofuran, 5:1 (tetrahydrofuran / water, v / v) water was added thereto, hydrolyzed at room temperature for 1 hour, and after solvent and water were removed, 30% ethylene glycol substituted with a hydroxyl group at the end was obtained. Methoxyethoxy 70% substituted polyphosphazene (PEP-3).

[0051] PEP-3 (1.87g) and D, L-lactide 4.33g, under the protection of an inert atmosphere (argon or nitrogen), add 0.006g of stannous isooctanoate, and then under vacuum conditions (below 15Pa) React at 140°C for 12 hours to obtain poly(D,L-lactide) grafted polyphosphazene. The graft ratio of poly(D,L-lactide) is 30%, and the average segment length is 10 lactic acid units.

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Abstract

The invention relates to a biodegradable polyester grafted polyphosphazene copolymer and a preparation method thereof. A biodegradable polyphosphazene copolymer prepared by directly initiating the ring-opening polymerization of lactone monomers by linear polyphosphazenes substituted with hydroxyl side groups. By selecting different kinds of second or third co-substituting groups, and by controlling their degree of substitution, the hydrophilicity, degradation performance, biocompatibility and cell affinity of the polyester graft copolymer are adjusted, To meet the requirements of different medical uses. The aliphatic polyester grafted polyphosphazene copolymer of the invention has excellent biodegradability, biocompatibility and non-toxicity.

Description

Technical field: [0001] The invention relates to a biodegradable polyester grafted polyphosphazene copolymer and a preparation method thereof. Background technique: [0002] Biodegradable polymers are polymers that can be hydrolyzed, or degraded by enzymes and microorganisms, resulting in a decrease in molecular weight, loss of strength, and final degradation into small molecules, monomers, or carbon dioxide and water. After using biodegradable polymers as medical sutures, bone nails or other medical repair materials, since the materials will degrade and metabolize in the body, they will eventually be excreted from the body or absorbed by the body, thus eliminating the need for repair after organ repair. It is troublesome to take them out; such materials can also be used as drug carriers to achieve long-term controlled release and constant rate release of drugs, and maintain the activity of biologically active substances, etc. Therefore, biodegradable polymers have a very i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/08C08G63/692C08G63/78
Inventor 蔡晴金日光张腾
Owner BEIJING UNIV OF CHEM TECH
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