Surgical site prepn. compsn. for skin surface

A technique of surgery, composition, applied in the direction of topical antibacterial agents, applications, biocides, etc., which can solve the problems of irritants, no long-lasting effect, limited utility, etc.

Inactive Publication Date: 2000-06-07
BECTON DICKINSON & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also problems with using alcohol as it has limited utility as an antimicr

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The detergency of the film-forming antiseptic composition for surgical sites of the present invention was demonstrated by pouring a small volume of a composition containing 1% chlorhexidine gluconate onto a piece of fabric. The fabric is then dried and washed with a solution of chlorine bleach and detergent. The laundered fabrics showed no trace of staining from the composition. A single piece of fabric was similarly treated with a 1% solution of chlorhexidine gluconate in ethanol. Wash the fabric with a solution of chlorine bleach and detergent. The laundered fabric exhibited a brownish stain.

Embodiment II

[0033] membrane integrity

[0034] Films cast from various compositions were tested for smoothness, sheeting and cracking. Films formed with Composition No. 1 were acceptable although slightly tacky, cruddy, and cloudy. Films cast from compositions Nos. 2, 3, and 4 were uniform with no cracking or exfoliation. Films cast with composition No. 5 in the examples were acceptable. However, the quality of the film was not very good because cracks occurred in the film. Similarly, the quality of films cast with compositions Nos. 6, 7 and 8 decreased when the concentration of chlorhexidine was decreased from 0.01% to 0.001%.

[0035] laundry stains

[0036] Compositions Nos. 1 and 2 were used to test the staining properties of the surgical site film-forming antiseptic compositions of the present invention. When a small volume of Composition No. 1 was applied to fabric and the fabric was washed in a solution of chlorine bleach and detergent, the fabric was stained. However,...

Embodiment III

[0040] components

[0041] film casting

[0042] Films formed from the following compositions

[0043] The above results clearly show that chlorhexidine gluconate is uniquely able to act as a binder for the film and produce a homogeneous film.

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PUM

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Abstract

An antimicrobial film forming surgical site preparation composition includes a film forming material and an antimicrobial agent soluble in a fugitive solvent. The composition when applied to the skin surface forms a substantially water insoluble, substantially tack-free flexible film adherent to the skin surface. The film is capable of releasably retaining the antimicrobial agent to substantially inhibit microbial growth on the skin surface. The film releases sufficient antimicrobial agent to substantially eliminate the microorganisms normally present on the skin surface to prepare the surface for the procedure and continues to release the antimicrobial agent during the procedure and subsequent wound healing. The composition can be easily washed from fabric and does not stain the fabric even where the fabric is treated with chlorine bleach. In addition, a smooth continuous film is formed without the use of a separate plasticizer.

Description

field of invention [0001] The invention involves a preparation composition for a surgical site. More specifically, the present invention involves a preparation composition for the surgical site of a film -containing film -containing film that is released on the skin. More particularly, the present invention relates to a film-forming antimicrobial composition for surgical sites which has improved film-forming characteristics and which can be easily laundered from hospital bedding. Background of the invention [0002] A variety of microorganisms are present on the surface of normal skin. As long as the surface of the skin is complete, these microorganisms are generally attached to the body without difficulty, so as to achieve certain natural balances. When a surgical surgery that breaks this natural barrier formed by the skin is to prevent these normal microorganisms from entering the wound. [0003] Various protocols aimed at reducing or eliminating skin microbes have been...

Claims

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Application Information

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IPC IPC(8): A61L15/44A01N47/44A61L26/00
CPCA61L26/0023A01N47/44A01N25/24C08L1/26A61P31/02A01N2300/00
Inventor 默罕穆德·A·克汉明·Q·霍昂
Owner BECTON DICKINSON & CO
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