Thymosin peptide oral tablet and its preparation method
A technology of thymosin and oral tablets, applied in the field of new drugs, can solve the problems of instability, loss of biological activity of thymosin, inconvenient use, etc.
Inactive Publication Date: 2007-02-14
卢建军
View PDF5 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Thymosin injection is administered intramuscularly or intravenously, which is inconvenient to use and causes pain to patients due to long-term medication
Thymosin enteric-coated tablets are administered orally and are unstable in the gastrointestinal tract and are easily destroyed by proteases in the gastrointestinal tract, making thymosin lose its biological activity
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreExamples
Experimental program
Comparison scheme
Effect test
Embodiment 5
[0017] The 1000 thymosin oral tablets of the present embodiment 5 are made of 2g thymosin, 518g starch, 270g sucrose, 100g sorbitol, and 12g magnesium stearate. Each tablet contains 2mg thymosin peptide. The preparation method is as follows: mix thymosin, starch, sucrose and sorbitol according to the prescription quantity, use 200ml of ethanol with a percentage concentration of 70% to make a soft material, granulate with a sieve with a pore size of 1.3mm, and dry at a temperature of 50°C , pass through a mesh sieve with an aperture of 1.60mm, and use a shallow concave punch of φ12mm to punch the tablet.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
A new medicine of oral tablet of thymosin is provided in the invention. It is prepared by 1 part of thymosin and 0-450 parts of pharmaceutical adjuvant by weight. At least 2mg thymosin peptide is contained in each oral tablet of thymosin, the pharmaceutical adjuvant should be one of the following ingredients: mannite, crystalline cellulose, lactin, starch, polyvinyl pyrrolidon, alcohol, hypromellose, carbomer934, magnesium stearate, gelatin, saccharose, glucose and sorbitol. The preparation process of the oral tablet of thymosin is also provided.
Description
Technical field: [0001] The invention relates to a new drug-thymosin oral tablet and a preparation method thereof. Background technique: [0002] Thymosin is a medicine extracted from animal thymus organ, which is a mixture of polypeptides with a molecular weight of 200-15,000. Thymosin is used for adjuvant treatment of various primary or secondary T cell deficiency diseases, various diseases with low cellular immune function and tumors. Thymosin injection is administered intramuscularly or intravenously, which is inconvenient to use, and long-term medication also causes pain to patients. Thymosin enteric-coated tablets are administered orally, and are unstable in the gastrointestinal tract, and are easily destroyed by proteases in the gastrointestinal tract, causing thymosin to lose its biological activity. Invention content: [0003] The purpose of the present invention is to overcome the above disadvantages and provide a thymosin oral tablet which is convenient for ad...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): A61K38/17A61K9/20A61P35/00A61P43/00
Inventor 卢建军
Owner 卢建军