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Preparation of sustained released strips of chitin homandren tablet

A technology of chitosan methyltestosterone and sugar methyltestosterone is applied in the field of preparation of chitosan methyltestosterone sustained-release drug strips, and can solve the problems of death, short action time, broodstock injury and the like

Inactive Publication Date: 2007-03-28
INST OF AQUATIC LIFE ACAD SINICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the principle of fish gonad development and sexual maturation, traditional fish artificial reproduction techniques usually use multiple direct injections of exogenous sex hormones or steroid hormones to accelerate the development of parent fish gonads. Short time, too many operations, serious injuries to broodfish, and even postpartum death and many other problems
Moreover, for fish that are sterile due to insufficient secretion of gonadotropins, or whose gonadal development is delayed, it is not appropriate to expect the traditional injection of exogenous hormones to promote their gonadal development

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] The steps are:

[0010] Prepare chitosan methyl testosterone medicine bar: A: Chitosan is made into the aqueous solution that mass and volume ratio concentration is 2% with 1.5-2% acetic acid solution (volume ratio of acetic acid and water), filters; B: shell Mix the polysaccharide solution and methyl testosterone at a volume-to-mass ratio of 2-3:1; C: use a syringe to push into the 5% NaOH coagulation solution, and place it for 10 or 11 or 12 or 13 or 15 minutes, carefully Take out; D: After rinsing with distilled water for 6 or 7 or 8 times continuously, bake at 58-60° C. for 16 or 17 or 18 or 19 or 20 or 22 or 24 hours to obtain chitosan methyl testosterone strips.

[0011] Subcutaneous implantation of medical strips: Carp were anesthetized with Eugenol, and blood samples were taken and weighed, and then chitosan-MT medical strips were implanted subcutaneously, and the implantation dose was controlled within the range of 30-80mg / 500g fish body weight. Use a scalpel ...

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PUM

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Abstract

A slow-releasing strip medicine for promoting the development of fish's gonad is prepared through preparing the aqueous solution of chitosan, filtering, proportionally mixing it with methyl testosterone, injecting the mixture in NaOH gel, laying aside, rinsing with distilled water, and baking.

Description

technical field [0001] The invention relates to a preparation method of a chitosan methyltestosterone slow-release medicinal strip, the medicinal strip prepared by the method can be used to promote the gonad development of fish, and especially relates to recovery from insufficient secretion of gonadotropin (gonadotropin, GtH). And lead to sterility, or the fertility of fish with gonad development retardation. Background technique [0002] The hypothalamus-pituitary-gonad is the endocrine center that regulates the reproductive activities of vertebrates. In teleosts, the gonadotropin-releasing hormone (GnRH) synthesized by the hypothalamus directly acts on the anterior pituitary through the axon terminal. Gonadotroph cells, combined with receptors distributed on their membranes, stimulate the pituitary gland to synthesize and release gonadotropin (GtH). Under the promotion of the slow and steady increase in gonadotropin secretion, fish gonads mature, and then ovulate, produce ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61K9/00A61P15/08
Inventor 胡炜朱作言黎双飞汪亚平
Owner INST OF AQUATIC LIFE ACAD SINICA