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Magnetic combine powder type vessel embolizing material

A technology of magnetic composite particles and vascular embolism, applied in medical science, prosthesis, etc., can solve the problems of expensive spring coils, prone to misembolization, invisible, etc., achieve ideal use effect, avoid misembolization, and facilitate observation

Inactive Publication Date: 2007-08-08
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Absorbable solid embolic materials are generally only used for preoperative embolization and short-term embolization therapy, and because they are X-ray transparent, they need to be mixed with contrast agents, and the application range is getting smaller and smaller; the expensive price of coils restricts their use; The technology of detachable balloon positioning is relatively complicated, and the filling degree of the balloon is difficult to control; commonly used PVA particles are invisible under X-ray and are easy to stick to microcatheters; liquid embolic materials are difficult to operate and prone to misembolization

Method used

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  • Magnetic combine powder type vessel embolizing material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Magnetic composite granular vascular embolism material, made of barium ferrite (BaFe 12 o 19 ) particles and polyurethane with a particle diameter of 1 to 100 μm, the mass ratio of each component is: barium ferrite (BaFe 12 o 19 ) particles 30%, polyurethane 70%, barium ferrite particles uniformly distributed in the polyurethane; the specific gravity of the magnetic composite granular vascular embolism material is 1.35.

[0013] The preparation method of the above-mentioned magnetic composite particle type vascular embolism material: select polyurethane with a particle diameter of 1-100 μm, mix with barium ferrite particles accounting for 30% by mass, mix and stir, cold press in a mold, and sinter to form energy The granular structure suspended in the blood, the diameter of the particles is 100 μm to 1000 μm, according to different clinical requirements, screened into different specifications, that is, the magnetic composite particle type vascular embolism material is...

Embodiment 2

[0016] The magnetic composite particle type vascular embolism material is composed of iron ferric oxide particles and polyurethane with a particle diameter of 1-100 μm. The mass ratio of each component is: ferric oxide particles 20%, polyurethane 80%, iron ferric oxide The particles are evenly distributed in the polyurethane; the specific gravity of the magnetic composite particle type vascular embolism material is 1.1.

[0017] The preparation method of the above-mentioned magnetic composite particle-type vascular embolism material: select polyurethane with a particle diameter of 1-100 μm, mix with ferric oxide particles accounting for 20% by mass, mix and stir, cold-press in a mold, and form energy after sintering. The granular structure suspended in the blood, the diameter of the particles is 100 μm to 1000 μm, according to different clinical requirements, screened into different specifications, that is, the magnetic composite particle type vascular embolism material is obta...

example 3

[0019] The magnetic composite granular vascular embolism material is composed of barium ferrite particles and trans polyisoprene with a particle diameter of 1-100 μm. The mass ratio of each component is: barium ferrite particles 40%, trans polyisoprene The polyisoprene is 60%, and the barium ferrite particles are evenly distributed in the trans polyisoprene; the specific gravity of the magnetic composite particle type vascular embolism material is 1.26.

[0020] The preparation method of the above-mentioned magnetic composite particle type vascular embolism material: select trans-polyisoprene with a particle diameter of 1-100 μm, mix with barium ferrite particles accounting for 40% by mass, mix and stir, and cool in a mold After pressing and sintering, a granular structure that can be suspended in the blood is formed. The diameter of the particles is 100 μm to 1000 μm. According to different clinical requirements, they are screened into different specifications to obtain magnet...

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Abstract

The present invention relates to one kind of blood vessel embolizing intervention material. The composite magnetic granular blood vessel embolizing material features that it consists of magnetic grains in 20-40 wt% and shape memory polymer material in 60-80 wt%, with the magnetic grains being dispersed homogeneously inside the shape memory polymer material. The present invention as one kind one ideal blood vessel embolizing intervention material has excellent suspension property, can enter the pathological change part for close embolism, and makes it possible to observe the embolized part conveniently to avoid error embolism.

Description

technical field [0001] The invention relates to a blood vessel embolic material for intervention, especially a microvessel or peripheral blood vessel embolic material. Background technique [0002] In the prior art, there are many kinds of vascular embolic materials for intervention, mainly solid embolic materials, such as absorbable solid embolic materials such as autologous blood clot, gelatin sponge, hemostatic agent and occlusive glue, microcoils, and detachable balloons. Non-absorbable solid embolic materials such as particles and particles; liquid embolic materials, such as n-butyl α-cyanoacrylate (NBCA), vinylidene alcohol heteropolymer (EVAL), and cellulose acetate polymer (CAP). Absorbable solid embolic materials are generally only used for preoperative embolization and short-term embolization therapy, and because they are X-ray transparent, they need to be mixed with contrast agents, and the application range is getting smaller and smaller; the expensive price of c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44
Inventor 李世普戴红莲黄健曹献英黄福龙王欣宇韩颖超贾莉邵海成
Owner WUHAN UNIV OF TECH