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New type antibiotic peptide of peptaibol and preparing technique

A technology of piperomycin and trichoderma, applied in the field of new antibiotic peptide-piperomycin, can solve the problems of restricting in-depth research and application, high synthesis cost, and achieve the effect of not easy drug resistance and good inhibitory effect.

Inactive Publication Date: 2007-08-22
SHANDONG UNIV
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  • Summary
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  • Description
  • Claims
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Problems solved by technology

But the pipepermycin currently used for research is almost all synthesized, and the synthesis cost is very high. How to produce high-purity pipepermycin in large quantities has become a difficult problem restricting its in-depth research and application

Method used

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  • New type antibiotic peptide of peptaibol and preparing technique
  • New type antibiotic peptide of peptaibol and preparing technique
  • New type antibiotic peptide of peptaibol and preparing technique

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Preparation of liquid strains for production

[0031] Culture medium: 11 parts of bran, 6 parts of potato, and 100 parts of water, all in parts by weight, the same below. Boil, filter, add 0.6 parts of peptone, Na 2 HPO4 0.5 parts, KH 2 PO 4 0.04 parts, sterilized, cooled, inoculated with 10 parts of secondary liquid strains of Trichodermakoningii SMF2, ventilated and stirred, cultivated for 34 hours, and used as liquid strains for production.

[0032] (2) Trichoderma fermentation culture prepared by thick-layer ventilated fermentation

[0033] Raw material: 35 parts of wheat straw powder, 70 parts of bran, 2 parts of ammonium sulfate, all are parts by weight, moisten water, raw material: water=1: 3.0 (weight ratio), sterilization, cooling, the production of inoculation step (1) Use 7 parts (weight) of liquid strains, transfer to aseptic solid fermentation koji pond, lead to aseptic wind, at 25~28 ℃, ferment under 80~85% relative air humidity, turn over koji on...

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Abstract

A pipomycin as a novel antibiotic peptide is prepared from Trichoderma through solid and liquid fermenting in aseptic GMP environment, and two-step separation. Three pipomycins are prepared, which feature broad-spectrum bacterium suppressing activity, so it can be used to prevent and eliminate the diseases and pests of plant.

Description

(1) Technical field [0001] The invention relates to the separation and preparation of a novel antibiotic peptide-piperamycin from a fermentation product of Trichoderma, belonging to the field of biotechnology. (2) Background technology [0002] Chemical pesticides have made important contributions to the prevention and control of diseases, insects, weeds and rodents. However, with the large-scale application of chemical pesticides, the problem of "3R" (that is, drug resistance, Resurgence, and pesticide residue Residuce) has become more and more serious, seriously affecting agricultural products. Food safety has become one of the main restrictive factors for my country's agricultural products to enter the international market. It is an inevitable trend that a large number of chemical pesticides with high toxicity, high residue and killing natural enemies will gradually be restricted in use until production is completely banned. According to the statistics of the Food and Agr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K11/00C12P21/02A61K38/04A61P31/04A61P31/10
Inventor 张玉忠宋晓妍孙彩云解树涛陈秀兰
Owner SHANDONG UNIV
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