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Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor

A compressed air and aerosol technology, applied in the direction of inhalers, aerosol delivery, nebulizers for treatment, etc., can solve the problems of insufficient metering and drug efficacy, and achieve the effect of easy expansion of production

Inactive Publication Date: 2002-03-06
马克思－德布鲁克－分子医学中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The result is insufficient dosing and potency

Method used

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  • Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor
  • Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor
  • Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols suitable therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] according to figure 1 As shown, the compressed air inhaler mainly consists of a nozzle body 1 with a compressed air delivery channel 16 and a liquid delivery channel 14 , a balancing drying container (spray chamber) 17 and an aerosol outlet (mouthpiece) 18 . The liquid delivery channel 14 is connected to a liquid meter 19 and a container 20 for an aqueous lipid dispersion.

[0022] In order to regulate the pressure, the delivery channel 16 is connected to a pressure reducer, not shown in the figure.

[0023] The nozzle body 1 forms a two-substance nozzle, in which the supplied liquid is atomized by means of compressed air supplied in a pressure-adjustable manner. The high-efficiency substance is generally dissolved in the delivered liquid, such as water or ethanol, where it exists as a dispersion. The air flow and the liquid flow can be adjusted independently of each other.

[0024] according to figure 2 As shown, the nozzle body 1 is mainly composed of a central c...

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PUM

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Abstract

The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention is to provide an inhaler by means of which the pulmonary application of especially liposomes that carry active agents is possible without forced breathing manoeuvres and by means of which the active agent can be transferred to the desired place of action in a sufficient amount without the active agent escaping. To this end, said compressed air inhaler comprises a receptacle (20) for the aqueous dispersion of liposomes. The liposomes carrying the active agents are dispersed in water in said receptacle. The receptacle is connected to an anatomising nozzle (1) and to a drying unit (17) via a device that doses liquids (19), whereby the drying unit can be an atomising chamber for spray drying the liposomes. An outlet (18) and a mouth piece are joined to said drying unit. The anatomising nozzle (1) is provided with separate supply channels (14, 16) for the compressed air and the dispersion of the liposomes. The invention also relates to a novel powder aerosol consisting of liposomes or nanoparticles.

Description

technical field [0001] The present invention relates to a compressed air inhaler for spraying lipid powder aerosols loaded with high-potency substances or without high-potency substances to the lungs. [0002] The present invention is preferably intended for lipid powder aerosols loaded with high potency substances. However, the invention can also be used for liposomes which do not contain potent substances, for example liposomes composed of special lipids, such as surfactant lipids, which can themselves be potent substances. [0003] Furthermore, the subject of the invention is a powder aerosol with or without a potent substance, which can be used in a compressed-air inhaler. Background technique [0004] Liposomes are gaining in importance as a delivery form of highly potent substances. In order to improve the physical stability and lipid persistence and maintain the encapsulated potent substance, the lipid formulation loaded with potent substance was lyophilized. But l...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K9/00A61K9/127A61K9/16A61K9/51A61K9/72A61K47/24A61K47/28A61K47/32A61K47/34A61K47/36A61K47/42A61L9/12A61M11/02A61M11/06A61M15/00A61P11/00B05B7/00B05B7/06
CPCB05B7/066B05B7/0012A61K9/127A61M15/0086A61K9/0075A61K9/0078A61M11/06A61K9/1277A61K9/1272A61M11/001A61P11/00A61P11/06A61P11/08A61M15/00B82Y30/00
Inventor 尤利娅·埃娃·迪德里希斯沃尔夫冈·科赫胡贝特·勒丁雷吉娜·雷斯卡霍斯特·温特
Owner 马克思－德布鲁克－分子医学中心
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