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Process for preparing phenylacetamide

A technology of phenylacetamide and production method, applied in the production field of phenylacetamide, can solve the problems of low overall yield and quality, and achieve the effects of easy pressure control, high yield and good quality

Inactive Publication Date: 2002-04-03
谌文燊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Phenylacetamide is the main raw material for the preparation of penicillin G medium, and is also an important raw material in organic chemical synthesis. In the past, this raw material relied on imports. In recent years, with the needs of the development of my country's pharmaceutical industry, there has been a small amount of production, but the overall yield, low quality

Method used

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Embodiment Construction

[0024] In a 1300 liter autoclave, the feeding amount is 100kg of styrene and 60.8kg of sulfur. It is calculated that the volume of the aqueous solution in which all the sulfur is converted into hydrogen sulfide and can be dissolved is 808L, and the amount of liquid ammonia used is 24% of the volume, which is about 182.4kg[ Water volume: (60.8 / 32×34)÷8%=808L, ammonia consumption: 808×24%=182.4kg], reaction temperature is 160°C, pressure 35kg / m 2 The yield of finally obtained phenylacetamide is 99%, and the purity reaches 99%.

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Abstract

A process for preparing phenyl acetamide features the reaction of styrene on sulfur in mole ratio of 1:(1.9-2) in the existance of liquid ammonia. Its advantages are high output rate up to more than 95% and high purity up to 99%.

Description

technical field [0001] The invention relates to the field of chemical synthesis, in particular to a production method of phenylacetamide. Background technique [0002] Phenylacetamide is the main raw material for the preparation of penicillin G medium, and is also an important raw material in organic chemical synthesis. In the past, this raw material relied on imports. In recent years, with the needs of the development of my country's pharmaceutical industry, there has been a small amount of production, but the overall yield, The quality is not high. Contents of the invention [0003] The technical problem to be solved by the present invention is to optimize the best preparation method on the basis of the existing production route, and improve the yield and quality of phenylacetamide. [0004] The current industrial production method of phenylacetamide adopts styrene to obtain after high-pressure reaction in the presence of sulfur and liquid ammonia, and its synthesis equa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/10C07C233/11
Inventor 谌文燊
Owner 谌文燊
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