Amorphous Adefuweizhi ester amorphous solid matter and its prepn

Adefovir dipivoxil and amorphous technology, which is applied in the field of adefovir dipivoxil amorphous solidified products and its preparation, can solve the problems of high cost, cumbersome operation, difficult medicine, etc., and achieve low cost, convenient operation, manufacturing and Formulated for easy effects
CN1374314AInactive Publication Date: 2002-10-16上海仲夏化学有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
上海仲夏化学有限公司
Publication Date
2002-10-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is amorphous Adefuweichi ester solid matter and its preparation process. The amorphous Adefuweichi ester solid matter is solid powder obtained through solidifying oil amorphous Adefuweichi ester and has, X-ray test shows, at least 80% amorphous component. The amorphous Adefuweichi ester solid matter of the present invention is easy to filter and dry, has excellent flowability and bulk density performance, and the present invention makes it easy to produce medicine composite containing Adefuweichi ester and its suitable for industrial production.
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Description

technical field

[0001] The invention relates to the field of medicinal chemistry, in particular to an amorphous cured product of adefovir dipivoxil and a preparation method thereof. Background technique

[0002] The chemical name of Adefovir Dipivoxil is: 9-[2-[bis(pivaloyloxymethoxy)phosphonomethoxy]ethyl]adenine. Adefovir dipivoxil is a new type of antiviral drug, it can be used for the treatment of human or animal retrovirus infection (HIV, SIV, FIV), hepatitis B virus or other hepatitis virus, DNA virus infection (human cytomegalovirus virus or herpes virus, such as HSV1 or HSV2), etc. European Patent EP481214; Starrett et al., J.Med.Chem., 1994, 37:1857-1864; Starrett et al., Antiviral Res., 1992, 19:267-273; Benzaria et al., J.Med.Chem., 1996, 39 : 4958-4965; Zhang Yong et al., Journal of Shenyang Pharmaceutical University, 2001, 18(2): 95-97. Usually, adefovir dipivoxil is obtained in the form of oil, which causes certain difficulties in the preparation of the drug...

Claims

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