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Process of extracting tannic acid from Geranium wilfordii root and the use of the extractive

An extraction method and technology of geranium, applied in the field of extraction of tannic acid from geranium tuber and its extract, can solve the problems of inconvenient use and insignificant curative effect, and achieve the effect of convenient use

Inactive Publication Date: 2003-02-26
CHINESE MEDICINE INST SICHUAN PROV ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Inconvenient to use, and the curative effect is not significant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Extraction of water-soluble active parts:

[0050]Weigh 5kg of purified and dried geranium tubers, crush them into coarse particles (0.3-2mm), add 25,000ml of distilled water to soak, keep warm at 50°C, stir and leaching for 2 hours, and filter out the infusion; add 25,000ml to the medicinal residue Distilled water (repeatedly extracted three times); combine the three filtrates, pump the filtrate into a vacuum concentration tank, and concentrate in a vacuum (-0.085Mpa; 50°C) to a clear paste (weight of medicinal materials: weight of concentrated liquid = 24~1:1), add 5000 -10000ml. 95% ethanol, after stirring well, place it at low temperature (2-8°C) for 24 hours; pour out the supernatant, filter (or centrifuge), the filtrate is decompressed to recover ethanol (-0.085Mpa; 30-40°C), Concentrate to 5000ml (specific gravity 1.05-1.08). The concentrate is spray-dried to obtain 0.8-1.2kg of brown powder (containing 50-60% tannic acid).

Embodiment 2

[0052] Extraction of alcohol-soluble active parts.

[0053] Weigh 5 kg of purified and dried geranium root tubers, crush them into coarse particles (0.3-2 mm), add 25,000 ml of 60% (V / V) ethanol to soak, keep warm at 40 ° C, stir and leaching for 1.5 hours, and extract the leachate; , then add 25000ml of 60% ethanol (repeated three times); merge three times to filter out the infusion, pump the filtrate into a vacuum concentration tank, recover ethanol under reduced pressure (-0.085Mpa; 30-40°C), concentrate to (1:1), About 5000ml, add 10000ml distilled water and mix well; (2-8°C) stand for 24 hours; centrifuge (4000prm), filter, and concentrate the filtrate under reduced pressure (-0.085mMpa; 1.08). The concentrated solution is spray-dried to obtain 0.7-0.9kg of brown powder (containing 50-60% tannic acid).

Embodiment 3

[0055] Preparation of effective parts of high-content geranium root tuber:

[0056] Take 100 g of the effective parts of geranium (containing 50-60% tannin) prepared in [Example 1], add 1000-2000 ml of distilled water, fully stir and dissolve, place at low temperature (2-8) for 24 hours; the solution is centrifuged (4000prm), Take the supernatant and filter; add the filtrate into the treated macroporous polymer adsorption resin (D101) column; pass through the resin column at a flow rate (500ml / hour); rinse with distilled water (flow rate 500-1000ml / hour) to The washing solution was colorless; then eluted with 60% ethanol eluent (flow rate 500ml / hour), and collected the eluent (until the eluent flowing out was pale yellow). Ethanol (-0.085mpa; 30-40°C) and (-0.085mpa; 50-60°C) were recovered from the eluent under reduced pressure, and spray-dried to obtain a brown powder (tannin content ≥ 80%).

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PUM

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Abstract

An extraction process of tannic acid from Geranium wilfordii tuber root as raw material includes washing, drying, crushing to 0.2-5 mm granules, extracting by adding water of 3-10 times the material weight or ethanol of 30-90 vol% concentration at 20-70 deg.C, filtering the extracted liquid, concentrating the filtrate to obtain clear cream, water or alcohol deposition, laying a side at 2-8 deg.C, centrifugating, filtering, concentrating the filtrate while recovering ethanol, spray drying or vacuum drying the concentrated liquid to obtain the product with tannic acid content over 50%. The extractive of the present invention has obvious effects of resisting inflammation, stopping pain, stopping bleeding, etc..

Description

Technical field: [0001] The invention relates to an extraction method for extracting tannic acid from effective parts from root tuber of geranium geranium, a traditional Chinese medicinal material, and the application of the extract. Background technique: [0002] Geranium is a commonly used Chinese herbal medicine. The species of geranium recorded in the Chinese Pharmacopoeia (2000 edition, part one) are the dried aboveground parts of yak (Erodium Stephanianum Willd), geranium (Geranium wilfordii Maxim) or wild geranium (Geranium Carolinianum L.) , has the functions of dispelling rheumatism, dredging channels and collaterals, and stopping diarrhea and dysentery. Mainly used for rheumatic arthralgia, numbness and spasm, muscle and bone pain, diarrhea and dysentery. The main preparation is geranium ointment (anti-inflammatory, detoxification, astringent, granulation and other functions). [0003] In minority areas in western Sichuan, folks often use the root part of gerani...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/70A61P7/04A61P29/00C07H1/08
Inventor 谢道刚何廷炳
Owner CHINESE MEDICINE INST SICHUAN PROV ACAD OF CHINESE MEDICINE
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