Method for synthesizing theanine

Abstract

A process for synthesizing theanine features that L-pyrrolidone carboxylic acid and anhydrous ethylamine directly take part in reaction in inert gas atmosphere at 60-100 deg.c and 6-12 MPa to obtain L-theanine. Its advantages are high output rate up to 38%, and short reaction time.

Description

technical field [0001] The present invention relates to the synthetic method of theanine. Background technique [0002] Theanine (L-thiamine) is a characteristic amino acid of tea, which has various edible and medicinal functions. Its scientific name is N-ethyl-L-glutamine (N-ethyl-L-glutamine), and its structural formula is as follows: [0003] As early as 1942, Israeli Liechtenstein first used ethylamine and pyrrolidone acid to react in aqueous solution to obtain theanine in the laboratory. In 1951, Hashizubin of Japan improved the synthesis method, that is, using L-pyrrolidone carboxylic acid and pure ethylamine (instead of in aqueous solution) to react at low temperature, and the yield of theanine increased. [1] , but the response time takes one week to more than ten days, or even longer. [0004] In 1961, Y.Yamada et al. first formed L-pyrrolidone carboxylic acid into copper salt, and then reacted with pure ethylamine to synthesize theanine, so as to effectively uti...

AI Technical Summary

Problems solved by technology

Most methods are difficult to implement industrially

[0006] There has been no report on the industrial production of synthetic theanine in 60 years

[0007] Although the history of theanine synthesis has been more than half a century, due to reasons such as low yield and long cycle, it is still impossible to realize large-scale industrial production, which limits the application of theanine, and the price of imported theanine is extremely high. High cost (90×200mg capsules, the market price is as high as US$3195)