Method for synthesizing theanine

A synthesis method and technology of theanine, which is applied in chemical instruments and methods, preparation of carboxylic acid amides, preparation of organic compounds, etc., can solve the problem of high market price, inability to realize industrial production, and no industrial production of synthetic theanine And other issues

A synthesis method and technology of theanine, which is applied in chemical instruments and methods, preparation of carboxylic acid amides, preparation of organic compounds, etc., can solve the problem of high market price, inability to realize industrial production, and no industrial production of synthetic theanine And other issues

CN1415599AInactive Publication Date: 2003-05-07JINAN UNIVERSITY
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Embodiment Construction

[0017] L-glutamic acid undergoes intramolecular dehydration at 130-150°C to generate L-pyrrolidone carboxylic acid to protect the amino group. This method is the most environmentally friendly. After drying the resulting L-pyrrolidone carboxylic acid aqueous solution, add 50 grams of L-pyrrolidone carboxylic acid and 100 ml of anhydrous ethylamine in the autoclave, feed an inert gas (nitrogen, argon, etc.) under stirring, and control the specified pressure (5.0 ~10.0MPa), after reacting at 60~100°C for about 16~20 hours, release the pressure and recover ethylamine. After dissolving with a small amount of water, add alcohol to precipitate L-theanine, etc., separate, recrystallize, and dry the product. Alcohol can be recovered and reused by distillation, and amino acids including theanine, which is less dissolved, can be recovered from the kettle liquid [8] .

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Abstract

A process for synthesizing theanine features that L-pyrrolidone carboxylic acid and anhydrous ethylamine directly take part in reaction in inert gas atmosphere at 60-100 deg.c and 6-12 MPa to obtain L-theanine. Its advantages are high output rate up to 38%, and short reaction time.

Description

technical field [0001] The present invention relates to the synthetic method of theanine. Background technique [0002] Theanine (L-thiamine) is a characteristic amino acid of tea, which has various edible and medicinal functions. Its scientific name is N-ethyl-L-glutamine (N-ethyl-L-glutamine), and its structural formula is as follows: [0003] As early as 1942, Israeli Liechtenstein first used ethylamine and pyrrolidone acid to react in aqueous solution to obtain theanine in the laboratory. In 1951, Hashizubin of Japan improved the synthesis method, that is, using L-pyrrolidone carboxylic acid and pure ethylamine (instead of in aqueous solution) to react at low temperature, and the yield of theanine increased. [1] , but the response time takes one week to more than ten days, or even longer. [0004] In 1961, Y.Yamada et al. first formed L-pyrrolidone carboxylic acid into copper salt, and then reacted with pure ethylamine to synthesize theanine, so as to effectively uti...

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Application Information

Patent Timeline
07 May 2003
Publication
CN1415599A
IPC
C07C231/02; C07C237/06
Inventors
李炎; 王秀芬