Anti-cancer assistant medicine contg. 20(S)-protopanaxadiol as effective component, and its application

A technology of protopanaxadiol and anticancer drugs, which is applied to medical preparations containing active ingredients, organic active ingredients, drug combinations, etc., can solve the problems of strong toxic and side effects, clinical application limitations, etc., and achieve high product yield, The effect of low equipment cost and safe operation

Inactive Publication Date: 2003-05-21
HAINAN ASIA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some anticancer drugs successfully developed so far have a good effect on killing cancer cells, their clinical application is limited because of their strong toxic and side effects

Method used

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  • Anti-cancer assistant medicine contg. 20(S)-protopanaxadiol as effective component, and its application
  • Anti-cancer assistant medicine contg. 20(S)-protopanaxadiol as effective component, and its application
  • Anti-cancer assistant medicine contg. 20(S)-protopanaxadiol as effective component, and its application

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Experimental program
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Effect test

test approach 1

[0019] The pharmacodynamics research result of the present invention is as follows: 20 (S)-protopanaxadiol capsule is relevant to the main pharmacodynamics experiment summary of functional indication through transplantation tumor model in mice, to 20 (S)-protopanaxadiol Capsule anti-tumor effect, experimental research on the synergistic, attenuating effect and mechanism of the chemotherapeutic drug cyclophosphamide (CTX). The result shows that 20(S)-protopanaxadiol capsule has good anticancer activity, and 25,50,100mg / kg dosage group is to liver cancer H 22 The average tumor inhibition rates for Lewis lung cancer were 33.53%, 40.10%, and 49.47%, respectively; the average tumor inhibition rates for Lewis lung cancer were 30.5%, 37.2%, and 48.2%; for melanoma B 16 The average tumor inhibition rates were 40.87%, 41.77%, 45.27%. Moreover, 20(S)-protopanaxadiol capsules have obvious synergistic and attenuating effects on CTX. Through the analysis of NK, SI, IL-2, CD 3 、CD 4 、CD...

preparation Embodiment 2

[0176] Dissolve 200g of solid sodium hydroxide in 100ml of 1,4-butanediol, then add 10g of dry powder of total saponins from American ginseng stems and leaves, heat to 230°C under stirring for 150 minutes of hydrolysis reaction, and pour into 500ml of 25°C while the reaction is complete Dilute in water, mix evenly, filter under reduced pressure to obtain a precipitate, wash the precipitate three times with 150 ml of water each time, and vacuum dry the precipitate at 105° C. to obtain 6.0 g of the total hydrolyzed product. By silica gel column chromatography (eluent: chloroform:methanol=30:1 elution), 0.97g of 20(S)-protopanaxadiol crude product was obtained, and then the crude product was recrystallized from ethyl acetate to obtain white needle-like crystals 584mg, the yield is 5.84%, and its purity is greater than 98% as determined by HPLC. The needle-like crystals were tested by TLC, MS, 13 C-NMR, 1 H-NMR, 13 C- 1 H COZY, 1 H- 1 H COZY, specific optical rotation and me...

preparation Embodiment 3

[0177] Dissolve 160g of solid sodium hydroxide in 110ml of glycerol, then add 10g of dry powder of total saponins of American ginseng stems and leaves, heat to 235°C under stirring for 150 minutes of hydrolysis reaction, after the reaction is completed, pour it into 300ml of water at 25°C for dilution while hot, Mix evenly, filter under reduced pressure to obtain a precipitate, wash the precipitate three times with 100 ml of water each time, and vacuum-dry the precipitate at 105° C. to obtain 6.4 g of the total hydrolyzed product. By silica gel column chromatography (eluent: chloroform:methanol=30:1 elution), 1.40 g of the crude product of 20(S)-protopanaxadiol was obtained, and the crude product was recrystallized from ethyl acetate to obtain white needle-like crystals 619 mg, the yield is 6.19%, and its purity is greater than 98% as determined by HPLC. The needle-like crystals were tested by TLC, MS, 13 C-NMR, 1 H-NMR, 13 C- 1 H COZY, 1 H- 1 H COZY, specific optical ro...

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Abstract

The present invention provides an anticancer auxiliary medicine using 20(S)-protopanaxadiol as effective component and its application. Said medicine possesses the action of raising therapeutic effect of anticancer medicine, reducing toxicity of anticancer medicine, preventing and curing leukopenia due to radiotherapy and chemotherapy and raising immunity of human body, and can be used for auxiliary therapy of carcinoma.

Description

Technical field: [0001] The invention relates to an anti-cancer auxiliary drug for enhancing the curative effect of anti-cancer drugs, reducing the toxicity of anti-cancer drugs, preventing and treating leukopenia caused by radiotherapy and chemotherapy, and enhancing the body's immune function, which belongs to the medical field of cancer treatment. Background technique: [0002] Cancer is one of the diseases with the highest mortality in the world today, and its incidence and mortality have risen to the first place in some developed countries. At present, although remarkable progress has been made in the prevention and treatment of cancer, humans have not yet found a cure. Although some anticancer drugs successfully developed so far have a good effect on killing cancer cells, their clinical application is limited because of their strong toxic and side effects. Therefore, while people are constantly researching and developing new anticancer drugs, they are also actively st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P35/00
Inventor 金永日睢大员张辉李绪文张龙清楼金
Owner HAINAN ASIA PHARM CO LTD
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