Unlock instant, AI-driven research and patent intelligence for your innovation.

Slowly releasing tablet of ligustrazine of phosphoric acid and its preparing method

The technology of ligustrazine phosphate and sustained-release tablets is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, extracellular fluid diseases, etc. To achieve the effect of improving compliance, reducing the frequency of administration, and prolonging the duration of action

Inactive Publication Date: 2003-07-23
WUHAN UNIV
View PDF0 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ligustrazine phosphate is a traditional drug that can effectively treat ischemic cerebrovascular diseases, common preparations are excreted quickly, requiring frequent administration, and the peak-valley phenomenon is obvious

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Slowly releasing tablet of ligustrazine of phosphoric acid and its preparing method
  • Slowly releasing tablet of ligustrazine of phosphoric acid and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: ligustrazine phosphate sustained-release tablet, composed of 70% ligustrazine phosphate, 13% hydroxypropyl methylcellulose, and 17% ethylcellulose.

Embodiment 2

[0014] Embodiment 2: ligustrazine phosphate slow-release tablet, by 50% ligustrazine phosphate, 25% hydroxypropyl methylcellulose, 14% ethyl cellulose, 10% calcium hydrogen phosphate and 1% stearin Composition of magnesium oxide.

Embodiment 3

[0015] Embodiment 3: ligustrazine phosphate slow-release tablet, by 28% ligustrazine phosphate, 37% hydroxypropyl methylcellulose, 5% ethyl cellulose, 28% calcium hydrogen phosphate and 2% talcum powder composition.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A slow-released ligustrazine phosphate tablet is prepared from ligustrazine phosphate, hydroxypropylmethyl cellulose, ethyl cellulose and calcium hydrogen phosphate through proportioning, sieving by 40-80 meshes, mixing, wetting with alcohol, drying and tabletting. Its advantages are high curative effect, durable acting, and low poison.

Description

technical field [0001] The invention relates to ligustrazine phosphate sustained-release tablet and a preparation method thereof. Background technique [0002] Tetramethylpyrazine (tetramethylpyrazine, TMPZ) is called tetramethylpyrazine. It is one of the main chemical components in Rhizoma Chuanxiong, Rhizome of Zedoary Rhizome and Stem of Hemp Tree. It is reported that this product can improve microcirculation, inhibit platelet aggregation, prevent thrombus formation, improve renal ischemia and protect renal function. The existing dosage forms include tablets, capsules and injections, which have the characteristics of rapid absorption, wide distribution and rapid elimination mainly in the liver. The common tablet dosage of this product is 50mg / tablet, 3 times / day, 1-2 tablets / time. Although ligustrazine phosphate is a traditional drug that can effectively treat ischemic cerebrovascular diseases, common preparations are excreted quickly, requiring frequent administration,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4965A61K31/675A61P7/02A61P9/10
Inventor 何文丁虹周延安李荣凌罗顺德
Owner WUHAN UNIV