Medical aerosol formulation
A pharmaceutical preparation and preparation technology, applied in the field of medicinal aerosols, can solve the problems of increased mucosal irritation and no industrialization of insulin
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[0021] This application refers to U.S. Application Serial No. 09 / 158,369, filed September 22, 1998, which is incorporated herein by reference in its entirety.
[0022] The present invention relates to a stable suspension aerosol formulation suitable for pressurized delivery comprising (1) macromolecular pharmaceutical or drug particles, (2) a suitable propellant, and (3) a suitable stabilizer.
[0023] Suitable macromolecular agents or drugs are those suitable for administration by inhalation, where said inhalation is for oral and nasal inhalation therapy. Stable colloidal dispersions of drugs in fluids such as air, hydrocarbon gases, chlorofluorocarbon (CFC) propellants or non-CFC propellants such as tetrafluoroethane (HFA-134a) and heptafluoropropane (HFA-227) are described body.
[0024] Multiionic stabilizers such as amino acids and small molecule peptides are used as inactive formulation components that cause a decrease in the adhesive bond strength between drug particle...
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