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Medical aerosol formulation

A pharmaceutical preparation and preparation technology, applied in the field of medicinal aerosols, can solve the problems of increased mucosal irritation and no industrialization of insulin

Inactive Publication Date: 2003-09-03
AEROPHARM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because diabetes is a chronic disease that must be continuously treated by administering insulin, and because mucosal irritation tends to increase with repeated exposure to membrane penetration enhancers, efforts to develop non-invasive nasally administered insulin have not been industrialized

Method used

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Examples

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Embodiment Construction

[0021] This application refers to U.S. Application Serial No. 09 / 158,369, filed September 22, 1998, which is incorporated herein by reference in its entirety.

[0022] The present invention relates to a stable suspension aerosol formulation suitable for pressurized delivery comprising (1) macromolecular pharmaceutical or drug particles, (2) a suitable propellant, and (3) a suitable stabilizer.

[0023] Suitable macromolecular agents or drugs are those suitable for administration by inhalation, where said inhalation is for oral and nasal inhalation therapy. Stable colloidal dispersions of drugs in fluids such as air, hydrocarbon gases, chlorofluorocarbon (CFC) propellants or non-CFC propellants such as tetrafluoroethane (HFA-134a) and heptafluoropropane (HFA-227) are described body.

[0024] Multiionic stabilizers such as amino acids and small molecule peptides are used as inactive formulation components that cause a decrease in the adhesive bond strength between drug particle...

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PUM

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Abstract

A medicinal formulation is disclosed. The formulation comprises: a therapeutic amount of a protein or peptide medicament, a fluid for containing said medicament having a molecular size ranging from 1 K Dalton to about 150 K Daltons, a fluid carrier for containing the medicament, and a stabilizer selected from an amino acid, a derivative thereof or a mixture of the foregoing.

Description

[0001] This application claims priority to US Provisional Application No. 60 / 177,987, filed January 25, 2000, which is incorporated herein by reference. Background of the invention [0002] field of invention [0003] The present invention relates to pharmaceutical aerosols, more particularly to pharmaceutical aerosols comprising protective colloid stabilizers. [0004] Description of related technologies [0005] Drug delivery to the lungs by inhalation is an important means of treating a variety of conditions, including common local conditions such as cystic fibrosis, pneumonia, bronchial asthma and chronic obstructive pulmonary disease, and certain systemic conditions including pain management , immunodeficiency, hormone therapy, erythropoiesis, diabetes, etc. Steroids, β2 agonists, anticholinergics, proteins and polypeptides are drugs administered into the lung for such purposes. Such drugs are typically administered into the lungs in the form o...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K9/00A61K9/12A61K38/00A61K47/06A61K47/10A61K47/18A61M11/08A61M13/00A61M15/00C07D257/04
CPCA61K47/183C07D257/04A61K9/008
Inventor A·L·阿德杰Y·朱J·Z·孙S·斯特发诺斯
Owner AEROPHARM TECH
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