Crataegus leaf total flarone powder injection for treating heart and brain blood vessel disease and its preparation method

A technology for cardiovascular and cerebrovascular diseases and total flavonoids powder injection, which is applied in the field of drug preparation, can solve the problems of fast and effective treatment, low bioavailability, and long medication cycle for patients with cardiovascular and cerebrovascular diseases, and achieves narrowing of myocardial infarction. The effect of high area, high bioavailability and simple preparation method

Inactive Publication Date: 2003-09-17
广东八加一医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the hawthorn leaf preparations used clinically are oral preparations, which have slow onset of action, low bioavailability, and long medication cycle, so they are not suitable for rapid and effective treatment of patients with cardiovascular and cerebrovascular diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Hawthorn Leaf Total Flavonoids 50g

[0015] Meglumine 45g

[0016] Mannitol 50g

[0017] Povidone K30 10g

[0018] Take meglumine, mannitol, and povidone K30, add 4500 ml of water for injection, stir to dissolve, and continue heating. When the temperature rises to 80°C, add the total flavonoids of hawthorn leaves, keep warm, and stir until completely dissolved. Cool to room temperature, adjust the pH to 8.0 with 10% citric acid, adjust the volume to 5000ml, and filter through 0.65 μm and 0.22 μm microporous membranes respectively to obtain a clear filtrate. The filtrate is filled in a sterilized vial, freeze-dried, and after the freeze-drying is completed, the stopper is pressed, the cap is capped, the quality inspection is carried out, and the packaging is carried out to obtain the hawthorn leaf total flavonoids powder injection of the present invention.

Embodiment 2

[0020] Hawthorn Leaf Total Flavonoids 60g

[0021] Meglumine 50g

[0022] Mannitol 50g

[0023] Glucose 14g

[0024] Povidone K30 10g

[0025] Take meglumine, mannitol, glucose, povidone K30, add 4600ml of water for injection, stir to dissolve, and continue heating. When the temperature rises to 75°C, add the fine powder of total flavonoids from hawthorn leaves, keep warm, and stir until completely dissolved. Cool to room temperature 25°C, adjust the pH to 8.0 with 10% citric acid, adjust the volume to 5000ml, and filter through 0.65μm and 0.22μm microporous membranes respectively to obtain a clear filtrate. The filtrate is filled in a sterilized vial, freeze-dried, and after the freeze-drying is completed, the stopper is pressed, the cap is capped, the quality inspection is carried out, and the packaging is carried out to obtain the hawthorn leaf total flavonoids powder injection of the present invention. Pharmacodynamic test

[0026] 1. Therapeutic ...

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PUM

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Abstract

A powder injection of haw leaf general flavone for treating cardiovascular and cerebrovascular diseases is prepared from the haw heaf general flavone (20-85 wt.%) and water-soluble medical auxiliaries (15-80 wt.%). Its advantages are high curative effect, stability and biologic utilization rate, and quickly taking its effect.

Description

Technical field [0001] The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases, and also relates to a preparation method of the medicine for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Hawthorn is widely distributed in my country and is mainly produced in northern my country. It is a commonly used traditional Chinese medicine. Clinically used for digestion and stagnation, blood circulation and blood stasis. In recent years, it has been more widely used in the treatment of cardiovascular diseases and antibacterial and anti-inflammatory, which has attracted the attention and attention of scholars at home and abroad. Based on the study of hawthorn, chemical, pharmacological, and clinical studies on hawthorn leaves were also carried out, and it was found that its main chemical components are flavonoids and glycosides, which have the functions of lowering blood pressure, increasing coronary blood flow, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/352A61P9/10
Inventor 吴梅春
Owner 广东八加一医药有限公司
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