Daidzein drip pill and its preparation method

A technology of daidzein and aglycone dropping pills is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, which can solve the problems of affecting the curative effect of tablets and capsules, slow absorption, and low bioavailability.

Inactive Publication Date: 2003-09-17
耿燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But because of its water-solubility and fat-solubility are all quite poor, absorption in vivo is slow, and bioavailability is very low, has influenced the curative effect of existing tablet and capsule, and it is made dripping pill, improves its stripping speed and absorption speed in vivo, plays a role. to quick and efficient effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Now take processing 1000 dripping pills as an example, and the non-limiting examples are described as follows. Take daidzein (artificially synthesized or extracted from kudzu root), pulverize, pass through a 150-mesh sieve, and set aside.

[0012] 1. Put 34g of polyethylene glycol 4000 in a container, heat and melt it in an oil bath, put 6g of daidzein into the molten carrier, stir well, or use a homogenizer, milk homogenizer or colloid mill to mix evenly to make Pour the suspension into a thermal drop maker, select the appropriate dripper and dropping speed according to 1000 grains, drop the suspension into simethicone oil to form pellets, solidify, filter, and dry to obtain daidzein drops pill. Each pill weighs 40mg and contains 6mg of daidzein.

[0013] 2. Take 20 g of polyethylene glycol 6000 and 5 g of daidzein, and use Example 1 for processing. Each pill weighs 25mg and contains 5mg of daidzein.

[0014] 3. Take 24.6 g of polyethylene glycol 9000 and 5.4 g of ...

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PUM

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Abstract

A dropping pill of soybean aglycon is prepared from soybean aglycon, polyethanediol as carrier dimethyl silica oil as coolant, surfactant and stearic acid through proportionally mixing soybean aglycon with fused polyethanediol, surfactant and stearic acid, stirring, and dropping in the dimethyl silica oil.

Description

1. Technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a daidzein dripping pill and a preparation method thereof. 2. Background technology [0002] Daidzein is an active ingredient in kudzu root, which can be synthesized artificially. Daidzein can reduce myocardial oxygen consumption, increase blood flow in coronary arteries and cerebrovascular vessels, significantly improve symptoms such as headache, dizziness, and neck pain in hypertensive patients, significantly relieve angina pectoris, resist arrhythmia, resist oxidation, and strengthen the body Immunity, hypoglycemic and other pharmacological effects. It can expand the heart, brain and peripheral blood vessels, relieve vasospasm, improve microcirculation; reduce TXA2 / PGI2, inhibit platelet aggregation, reduce blood viscosity; improve menopausal syndrome, strengthen calcium absorption, prevent and treat neurosensory deafness and sudden onset Se...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61P3/10A61P7/02A61P9/06A61P9/10A61P9/12
Inventor 王宗贵吴家虎秦杰军耿燕
Owner 耿燕
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