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Furbenicillin antiseptic composite medicine

A technology of furbenicillin and furbenicillin sodium, which is applied in the directions of antibacterial drugs, active ingredients of heterocyclic compounds, etc., can solve the problems of increased bacterial resistance, difficulty in clinical treatment, endangering the life of patients, etc., and achieves strong antibacterial effect, Strong antibacterial ability and broad antibacterial spectrum

Inactive Publication Date: 2003-10-15
刘力
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Since the 1980s, due to the increase in the use of antibiotics and improper use, bacterial resistance has increased. For example, Streptococcus pneumoniae is an important pathogen of bacterial meningitis, otitis media, sepsis and pneumonia, and is the main cause of out-of-hospital infections in children. Pathogenic bacteria are the first pathogenic bacteria infected by adults, especially the elderly, due to the resistance of Streptococcus pneumoniae to penicillin and other β-lactam antibiotics, since the 1990s, penicillin-resistant pneumonia chain Cocci are widely spread around the world (foreign medicine, pharmacy volume 200027 (6) 344), the therapeutic effect of drugs decreases, endangering the lives of patients
Recently, there have been more reports on penicillin-resistant and cephalosporin-resistant Streptococcus viridans infection, which brings difficulties to clinical treatment
[0004] So far, there is no stable salt of furbenicillin (Furbenicillin) (Can. ) stable salt composition composition or reports of synergistic effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: The furbenicillin antibacterial combination drug is prepared from 0.25 grams of furbenicillin sodium and 0.0625 grams of potassium clavulanate to make a combined preparation, which is operated according to the powder injection preparation process.

Embodiment 2

[0015] Example 2: The present-furbenicillin antibacterial combination drug is prepared from 0.5 grams of furbenicillin sodium and 0.125 grams of potassium clavulanate to make a combined preparation, which is operated according to the powder injection preparation process.

Embodiment 3

[0016] Example 3: The furbenicillin antibacterial combination drug is prepared from 1 g of furbenzyl penicillin sodium and 0.25 g of potassium clavulanate to make a combined preparation, which is operated according to the powder injection preparation process.

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PUM

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Abstract

The antibiotic composite medicine consists of Furbencillin or its pharmacological salt, the pharmacological salt of Clavulanic acid or the pharmacological salt of Sulbactam. It has synergistic antibiotic effect more powerful than any of its single components.

Description

technical field [0001] The invention relates to the technical field of medicine and pharmacy, in particular to a furbenicillin antibacterial combination drug. Background technique [0002] Since the 1980s, due to the increase in the use of antibiotics and improper use, bacterial resistance has increased. For example, Streptococcus pneumoniae is an important pathogen of bacterial meningitis, otitis media, sepsis and pneumonia, and is the main cause of out-of-hospital infections in children. Pathogenic bacteria are the first pathogenic bacteria infected by adults, especially the elderly, due to the resistance of Streptococcus pneumoniae to penicillin and other β-lactam antibiotics, since the 1990s, penicillin-resistant pneumonia chain Coccus is widely disseminated in the whole world (foreign medicine, pharmacy fascicle 200027 (6) 344), the therapeutic effect of medicine declines, endangers the patient's life. [0003] Streptococcus viridans can cause men...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61P31/04
Inventor 刘力
Owner 刘力