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Composition of gensenoside Rg1 and ferulic acid for preventing and treating cardiac and cerebral vascular diseases and diabetes and its application

A technology of cardiovascular and cerebrovascular diseases and ginsenosides, which is applied in the field of biologically active compositions, medicines and foods, and can solve problems such as complex ingredients, unclear formula relations, and unrefined formulas

Inactive Publication Date: 2003-11-05
YUNNAN WUXIN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although traditional medicine has some compound prescriptions (such as compound salvia miltiorrhiza, etc.) for the prevention and treatment of cardiovascular and cerebrovascular diseases and diabetes, their components are complex, the relationship between the formulas is unclear, the prescriptions are not refined, and the quality is difficult to control.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Compound Ginsenoside Rgl and Ferulic Acid Jiangxuezhi Granules

[0061] formula:

[0062] Ginsenoside Rgl 95g

[0063] Ferulic Acid 5g

[0064] Sucrose 3000g

[0065] Dextrin 400g

[0066] Appropriate amount of ethanol is granulated according to the ordinary granulation method, and divided into 1000 bags (about 3.5g per bag). Take one bag each time, 1-2 times a day.

Embodiment 2

[0067] Embodiment 2: Compound ginsenoside Rgl and ferulic acid capsules

[0068] formula:

[0069] Ginsenoside Rgl 75g

[0070] Ferulic Acid 25g

[0071] Polyethylene glycol-400 300g is prepared according to the preparation method of ordinary capsules, the content of each capsule weighs about 400mg, and 1000 capsules can be obtained.

[0072] 35 patients with myocardial infarction were treated with this product. After 28 days of treatment, more than 95% of the patients were relieved to varying degrees, of which 55% were markedly effective and 40% were improved. The total effective rate of electrocardiogram is 66.4%.

Embodiment 3

[0073] Embodiment 3: Compound ginsenoside Rgl and ferulic acid freeze-dried powder injection

[0074] formula:

[0075] Ginsenoside Rgl 125g

[0076] Ferulic Acid 75g

[0077] Mannitol 100g

[0078] Prepare lyophilized preparations by common lyophilization method, and 1000 sticks of 200 mg compound ginsenoside Rgl and ferulic acid lyophilized powder injections can be obtained.

[0079] Pharmacodynamic test of compound ginsenoside Rgl and ferulic acid powder injection: Equal volume of normal saline (NS), compound Danshen injection and compound ginsenoside Rgl and ferulic acid powder injection were used as negative control group, positive control group and experimental group respectively. group, compound ginsenoside Rgl and ferulic acid powder injection antagonized pituitary hormone-induced reduction of isolated guinea pig heart coronary flow (p<0.01) in a dose-effect relationship, better than compound Danshen group. In anesthetized rats with ligated left anterio...

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PUM

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Abstract

The present invention relates to one composition of gensenoside Rg1 and ferulic acid for preventing and treating cardiac and cerebral vascular diseases and diabetes and its application. The composition consists of gensenoside Rg1 in 5-95 wt% and ferulic acid in 5-95 wt%. Through the synergistic function of gensenoside Rg1 and ferulic acid, the composition can regulate blood functions and treat diseases and disfunction caused by the change in blood system, cardiac and cerebral vascular system or blood sugar. The composition may be further prepared into medicine or food preparation by adding proper amount of supplementary material. The composition has high comprehensive treating effect.

Description

technical field [0001] The present invention relates to a composition for preventing and treating cardiovascular and cerebrovascular diseases and diabetes, in particular to a composition with biological activity composed of ginsenoside Rgl and ferulic acid, and the use of the composition in the preparation of medicines and food use. Background technique [0002] Research data confirm that ginsenoside Rgl can effectively improve the hemodynamics of blood circulation, reduce blood viscosity, reduce blood fat, and improve beauty. It is a commonly used natural extract and has pharmaceutical standards. Ferulic acid is one of the main components of Angelica and Chuanxiong. Ferulic acid has the functions of anti-oxidation, inhibition of platelet aggregation, anti-thrombosis, lowering blood fat, anti-myocardial ischemia, improvement of microcirculation, and beauty. Although ginsenoside Rgl and ferulic acid have certain curative effects on cardiovascular and cerebrovascular disease...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P3/10A61P9/10
Inventor 余树华
Owner YUNNAN WUXIN IND
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