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Detection of medical polyacrylamide hydrogel during its prepn

A polyacrylamide and preparation process technology, applied in the measurement of color/spectral characteristics, etc., can solve the problems of long time, high sample weighing accuracy, complex process, etc., and achieve the effect of short time, elimination of substandard products, and fast method.

Inactive Publication Date: 2003-11-05
吉林富华医用高分子材料有限公司
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AI Technical Summary

Problems solved by technology

This detection method, since the detection is the final product, so once unqualified, the product is waste
In addition, this method requires high accuracy of sample weighing, the process is more complicated, the time is long, and the error is large

Method used

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  • Detection of medical polyacrylamide hydrogel during its prepn
  • Detection of medical polyacrylamide hydrogel during its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] 1. Draw the working line of the relationship between the concentration C of the acrylamide monomer solution and the ultraviolet absorbance A.

[0011] The acrylamide monomer was prepared into 0.1mg / ml, 0.01mg / ml, 0.001mg / ml, 0.0001mg / ml, four standard concentration solutions with distilled water. Choose an ultraviolet light source that can emit a wavelength of 210nm. Use ultraviolet light of this wavelength to scan the solutions of the above four concentrations, and mark the four measured absorbances A on the plane coordinates 1-4 , connect each point to get the C-A relationship line of the accompanying drawing, and the equation is y=0.00067+0.001574x during conversion.

[0012] 2. Actual measurement

[0013] In the medical water with acrylamide as monomer, N, N dimethylbispropionamide as crosslinking agent; initiator composed of tetramethylethylenediamine, ammonium persulfate, sodium bisulfite and double distilled water as raw materials On the gel production line, t...

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Abstract

The present invention is detection method of medical polyacrylamide hydrogel in its preparation. Ultraviolet spectrophotometer is used in measuring the content of acrylamide monomer in the washing water of polymerization product. The specific process includes the following steps: compounding reference monomer solution in advance, measuring the ultraviolet absorbency A of reference solution in different concentration C, drawing C-A curve in planar coordinate, determining the range of qualified product, measuring the ultraviolet absorbency A1 of washing water in the preparing medical polyacrylamide hydrogel, comparing A1 with the C-A curve to find the monomer content. Compared with available liquid chromatographic process, the method has 60-100 times faster speed, and the method may be used directly in monitoring the production process.

Description

technical field [0001] The invention relates to a detection method of high molecular polymers, in particular to a detection method of unpolymerized monomers in medical polyacrylamide hydrogel. Background technique [0002] Polyacrylamide hydrogel has been widely used in the medical field, such as electrophoretic materials, wrapping materials, filling materials for human body defects, etc. Polyacrylamide hydrogel is used as a medical material, especially for filling the human body, and the content of unpolymerized acrylamide monomer is required to be controlled in a very small range. The current standard is 10 -6 (weight ratio of monomer to contained monomer gel) or less. Because acrylamide monomer and cross-linking agent are polymerized under the action of initiator, the monomer content in the polymer is much higher than the permitted standard. Therefore, in order to make polyacrylamide hydrogel meet medical requirements, There is also a post-polymerization reprocessing p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/33
Inventor 曹孟君
Owner 吉林富华医用高分子材料有限公司
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