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Compound preparation containing ribavirin and new decanoy acetaldehyde sodium and its preparation method

A new technology for sodium houttuyniacin and compound preparation, which can be applied in the field of medicine and can solve the problems of large toxic and side effects, limited wide application and the like

Inactive Publication Date: 2004-02-18
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ribavirin is an effective anti-influenza virus drug, but it is a chemical drug with high toxicity and side effects in conventional doses, which limits its wide clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 (freeze-dried powder for injection): take the prescribed amount of Houttuyfonate Sodium, add 14000ml of water for injection, heat to 70-80°C and stir to dissolve until clear; take another prescribed amount of ribavirin plus 6000ml of water for injection , heated and stirred to dissolve. After mixing the above two solutions, add the prescribed amount of Dextran S 40 , heated and stirred until the solution was clear. Add 20g of activated carbon, stir and adsorb for 30 minutes, filter to remove carbon, and adjust the pH to 6.0 with hydrochloric acid (1→10) solution. Filter through a 0.22μm microporous membrane, measure the content, and pack in 2.0ml each. It can be obtained by freeze-drying. Freeze-drying conditions: vacuum degree 750mmHg, pre-freezing temperature -40°C, pre-freezing time 2 hours; sublimation temperature -20°C, sublimation time 10 hours; first drying temperature 20°C, drying time 4 hours; second drying temperature 40 ℃, drying time 6 to 8 hour...

Embodiment 2

[0019]Embodiment 2 (powder for injection) In the aseptic operation room, take ribavirin and neohouttuycin sodium of the prescription amount, fully mix, and aseptically pack in 10ml vials, seal, press Aluminum cover will do.

Embodiment 3

[0020] Example 3 (injection) Take by weighing the prescribed amount of ribavirin and neohouttuyfonate sodium, add the prescribed amount of houttuyfonate sodium, add 14000ml of water for injection, heat to 70-80°C and stir to dissolve until clear; Prescribed amount of ribavirin plus water for injection 6000ml, heated and stirred to dissolve. After mixing the above two solutions, heat and stir until the solution becomes clear. Add 20g of activated carbon, stir and adsorb for 30 minutes, filter to remove carbon, and adjust the pH to 6.0 with hydrochloric acid (1→10) solution. Filter through a 0.22μm microporous membrane, measure the content, and pack in aliquots.

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PUM

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Abstract

A composite medicine in the form of injection for treating atypical pneumonitis, etc is prepared from medicine Libaweilin 50-2500 mg, sodium neohouttuyfonate 0.25-25 mg and medicinal auxiliary through heating, stirring, filter, and regulating pH value.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular it is a compound preparation containing ribavirin and neohouttuydin sodium and a preparation method thereof. Background technique: [0002] Since the outbreak of atypical pneumonia in Guangdong in February 2003, the Chinese Ministry of Health and the Administration of Traditional Chinese Medicine and other relevant agencies have successively issued a treatment plan for SARS and a traditional Chinese medicine "anti-SARS formula", including ribavirin. The Faculty of Medicine of the Chinese University of Hong Kong recently tested ribavirin, a specific drug for the treatment of atypical pneumonia, to see whether it can effectively reduce the number of viruses in the blood. The results of the trial show that the combination of ribavirin and steroids is currently performing well in Hong Kong, with a success rate of 95%. The World Health Organization and the U.S. Drug Control Center hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61P11/00A61P31/04A61P31/12A61P31/14
Inventor 唐星卢亚欣丁志毅何海冰丁怡
Owner SHENYANG PHARMA UNIVERSITY
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