Grain prolamin microsphere and preparation method

A gliadin and grain technology, applied in the directions of microcapsules, non-active components of polymer compounds, bulk delivery, etc., can solve problems such as being difficult to remove, achieve good containment efficiency, uniform particle size distribution, and reduce drug side effects. Effect

Inactive Publication Date: 2004-02-25
SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
View PDF1 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some toxic chemical solvents and reagents often remain in the microspheres prepared by chemical methods, which are difficult to remove. Using dimethyl sulfoxide (DMSO) as a solvent, heating and using a toxic bridging agent [Matsuda Y et al. Chem.Pharm.Bull., 37, 757-759(1989); Suzuki T et al.Chem.Pharm.Bull., 37, 1051-1054(1989).]

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Grain prolamin microsphere and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1.8 ml of absolute ethanol and 4 ml of water were mixed, then 400 mg of corn or wheat prolamin was added, and the mixture was vortexed to completely dissolve the substance (the prolamin content was 33.3 mg / ml).

[0023] 2. Under the circumstance that the above mixture is shaken violently, quickly add 8ml of water to mix the solution quickly to form a grain-containing gliadin-containing drug microsphere suspension (ethanol content 40%, gliadin 20mg / ml) .

[0024] 3. The suspension is vacuum-dried or freeze-dried to obtain cereal prolamin microspheres.

Embodiment 2

[0026] After diluting the 20 mg / ml cereal prolamin suspension prepared in Example 1 by 10 times, the measurement results of particle size distribution by light scattering are as follows: figure 1 shown. Wherein, the ordinate is the particle size distribution of the cereal gliadin microspheres, and the abscissa is the particle size (nm) of the cereal prolamin microspheres. It shows that the particle size distribution of the prepared cereal prolamin microspheres is between 500-1200 nm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Concentrationaaaaaaaaaa
Login to view more

Abstract

The present invention relates to a cereal alcohol soluble protein microsphere. Its grain size distribution is in 100-1500 nm. It is a method for preparing microsphere by utilizing phase separation method and using cereal alcohol soluble protein as membrane material. Said prepared microsphere can be used as base material for preparing passive target preparation.

Description

technical field [0001] The invention relates to a cereal-like prolamed egg microsphere with a particle size distribution of 100-1500 nm. The invention relates to a method for preparing microspheres by using a phase separation method with grain prolamin as a membrane material. Background technique [0002] Substances used as drug sustained-release materials should have good biocompatibility, be non-toxic, degradable in vivo and not induce antibody responses. Very few substances meet these requirements. Materials currently used for sustained drug release can be roughly divided into synthetic polymers such as polylactic acid (USP6143211) and natural polymers. Natural polymers contain polysaccharides and proteins. The latter are more limited in variety. Only ovalbumin (USP6007791) has been reported, because a bridging agent (often toxic) can be used to obtain particles with a size of about 500 nanometers, which is not suitable for human administration; collagen is too soft t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/16A61K9/50A61K47/42
Inventor 王瑾晔刘新铭
Owner SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products