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Novel medicine slow releasing preparation and its preparing method

The technology of a sustained-release preparation and a preparation method, which is applied in the field of pharmaceutical preparations, can solve the problems of low drug charge and insufficient initial release drug concentration, and achieve the effects of prolonging the drug release time and reducing the number of daily doses.

Inactive Publication Date: 2004-07-14
蔡玉臣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oral dosage forms of some drugs have the disadvantages of insufficient initial release drug concentration and low drug loading.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] formula:

[0022] Tablet core composition: Weight (kg) Tablet weight (mg)

[0023] Procainamide hydrochloride 10 1000

[0024] Hydroxypropyl methylcellulose 1.23 123

[0025] PvP 0.38 25

[0026] Carnauba wax 0.25 25

[0027] Silicone 0.05 5

[0028] Magnesium stearate 0.2 20

[0029] Water 300ml 25

[0030] Composition of coating film: Quantity (g)

[0031] Hydroxypropyl methylcellulose 12

[0032] Ethyl cellulose 18

[0033] Triethyl citrate 1.5

[0034] Ethanol: Chloromethane (1:1) 11

[0035] Preparation method: Add water to procainamide hydrochloride and mix in a mixer until lumps are formed. Add hydroxypropyl methylcellulose, PVP, carnauba wax and mix for 5 minutes. After the mixture is passed through a 40-mesh sieve, silica gel and magnesium stearate are added, fully mixed, and then compressed into tablets. Separately take hydroxypropyl methylcellulose, ethyl cellulose and triethyl citrate and dissolve them in a mixed solvent to obtain a coating solu...

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PUM

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Abstract

The present invention relates to one new type of slow released medicine preparation and the preparation process, and aims at raising initial releasing concentration and medicine loading amount for reaching stable medicine releasing performance of 12 hr. The present invention is suitable for Propranolol, Procainamide, adrenine and other common oral medicines. It has medicine core comprising main medicine, adhesive, corrosion agent, lubricant, stabilizer and water; and coating layer comprising hydrophilic polymer, hydrophobic polymer, plasticizer and solvent. It has medicine core accounting for 85-98 wt% of tablet, main medicine 70-90 wt%, and supplementary material in the medicine core and coating material less than 30 wt%. Compared with conventional tablet, the present invention has raised medicine content and thus less taking times and longer medicine releasing time.

Description

technology field; [0001] The present invention relates to a pharmaceutical preparation; in particular to a drug controlled release preparation. technical background; [0002] Oral dosage forms of drugs are the most common pharmaceutical dosage forms. However, the oral dosage forms of certain drugs have the disadvantages of insufficient initial release drug concentration and low drug loading. There has also been a controlled-release preparation prepared by blending PVP, gel and drug; after entering the gastrointestinal tract, the preparation contacts with digestive juice to form a low-solubility gel-like complex, which delays the release of the drug from the tablet produce a controlled release effect. However, its controlled release depends on the formation of complexes, and this process is not instantaneous. The drug on or near the surface dissolves rapidly within the first hour, producing an undesired peak; , The formation of colloidal complexes presents a controlled rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22
Inventor 蔡玉臣
Owner 蔡玉臣
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