Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dexibuprofen preparation and preparation method thereof

The technology of a preparation and an anti-adhesive agent is applied in the field of dextroibuprofen preparation and its preparation, which can solve the problem of not being able to meet the requirements of once-a-day dosing, not being able to rapidly reduce body temperature and analgesia, and not being able to achieve once-daily dosing, etc. problems, to achieve the effect of improving medication compliance, fast onset of action, and stable process

Pending Publication Date: 2021-06-04
海南慧谷药业有限公司
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation has 2 disadvantages: 1) slow onset after the drug is taken, can not quickly reduce body temperature and analgesia, is not conducive to controlling the disease, and even causes serious injury; 2) sustained release time is short, 10 hours release completely, can not reach daily Requirements for one dose, poor drug compliance
The release effect of the sustained-release pellets is limited. Dexibuprofen is completely released within 8 hours. It needs to be taken 2 to 3 times a day, which cannot meet the requirement of once-a-day administration, and the drug compliance is not good.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dexibuprofen preparation and preparation method thereof
  • Dexibuprofen preparation and preparation method thereof
  • Dexibuprofen preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0059] One embodiment of the present invention also provides a preparation method of Dexibuprofen preparation, comprising the following steps:

[0060] S110: Preparation of immediate release components, specifically:

[0061] Prepare the drug layer, and form an immediate-release film layer covering the drug layer on the outer surface of the drug layer to obtain an immediate-release component;

[0062] S120: Preparation of sustained-release components, specifically:

[0063] Prepare the drug layer, form an immediate-release film layer covering the drug layer on the outer surface of the drug layer, and then form a sustained-release film layer covering the immediate-release film layer on the outer surface of the immediate-release film layer to obtain a sustained-release component;

[0064] S130: mixing the immediate-release component and the sustained-release component to prepare a dexibuprofen preparation.

[0065] In some embodiments, step S110 includes the following steps: ...

Embodiment 1

[0083] Present embodiment is a kind of Dexibuprofen preparation, and the raw material that it adopts and preparation method are as follows:

[0084] (1) Immediate release component

[0085]

[0086] (2) Sustained release components

[0087]

[0088]

[0089] Preparation:

[0090] (1) Add hydroxypropyl methylcellulose, dextroibuprofen and sodium lauryl sulfate into the ethanol solution, stir evenly, add the sucrose ball core to the fluidized bed for preheating. The solution is sprayed and coated on the outer surface of the sucrose ball core by the fluidized bed bottom spray coating technology to make drug-containing pellets.

[0091] (2) Add hydroxypropyl methylcellulose into pure water, stir until completely dissolved, then add talcum powder, and stir evenly. The above drug-containing pellets are added to a fluidized bed for preheating. The solution is sprayed and coated on the drug-containing pellets by the fluidized bed bottom spray coating technology, and after...

Embodiment 2

[0097] Present embodiment is a kind of Dexibuprofen preparation, and the raw material that it adopts and preparation method are as follows:

[0098] (1) Immediate release component

[0099]

[0100] (2) Sustained release components

[0101]

[0102] Preparation:

[0103] (1) Add hydroxypropyl methylcellulose, dextroibuprofen, and sodium lauryl sulfate into the ethanol solution, stir to dissolve, and add the sucrose ball core to the fluidized bed for preheating. The solution is sprayed and coated on the outer surface of the sucrose ball core by the fluidized bed bottom spray coating technology to make drug-containing pellets.

[0104] (2) Add hydroxypropyl methylcellulose into pure water, stir until completely dissolved, then add talcum powder, and stir evenly. The above drug-containing pellets are added to a fluidized bed for preheating. The solution is sprayed and coated on drug-containing pellets by a fluidized bed bottom spray coating technology, and after coating...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a dexibuprofen preparation and a preparation method thereof. The dexibuprofen preparation comprises a quick-release component and a slow-release component, and the quick-release component comprises a drug layer and a quick-release film layer coating the drug layer; the slow-release component comprises a drug layer, a quick-release film layer coating the drug layer and a slow-release film layer coating the quick-release film layer; and the drug layers of the quick-release component and the slow-release component both contain dexibuprofen. The dexibuprofen preparation has the advantages of relatively long slow release time, low medication frequency per day and good medication compliance.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a dexibuprofen preparation and a preparation method thereof. Background technique [0002] Dexibuprofen is the S(+)-isomer of ibuprofen, and it is a non-steroidal antipyretic, analgesic and anti-inflammatory drug widely used clinically. Play anti-inflammatory, analgesic and antipyretic effects by inhibiting the synthesis of prostaglandins or other inflammatory mediators. It is clinically applicable to fever and headache caused by colds and other diseases; to reduce or eliminate mild and moderate pain or inflammation of the following diseases: sprains, strains, lower back pain, frozen shoulder, bursitis, tendon or tenosynovitis; dysmenorrhea, gout, toothache or postoperative pain; rheumatoid arthritis, osteoarthritis, and other seronegative (nonrheumatoid) joint diseases. Adverse reactions generally manifest as gastrointestinal discomfort or rash, headache, t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/62A61K31/192A61P29/00
CPCA61K31/192A61K9/5084A61K9/5078A61P29/00
Inventor 郭德解健博李致伟乔飞
Owner 海南慧谷药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com