Mannitol and sorbierite derivative
A technology for compounds and markers, applied in the field of composing oligomeric compounds and detecting nucleic acids, can solve the problems of low water solubility and inability to provide skeleton structure, and achieve the effect of avoiding separation steps.
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[0155] The oligomeric compounds of the invention can be synthesized by methods described in principle in the art and known to those skilled in the art. Particularly preferred building blocks are the compounds of the invention. Methods for preparing oligomeric compounds, such as specific sequence oligonucleotides and modified oligonucleotides, are known in the art and include, for example, cloning and restriction of appropriate sequences, and direct chemical synthesis. The chemical synthesis method may include, for example, the phosphotriester method described in Narang, S.A. et al., Methods in Enzymology 68 (1979) 90-98, the phosphodiester method disclosed in Brown, E.L. et al., Methods in Enzymology 68 (1979) 109-151, Beaucage et al., the phosphoramidite method disclosed in Tetrahedron Letters 22 (1981) 1859, the H-phosphate method disclosed in Garegg et al., Chem. Scr. 25 (1985) 280-282, and the solid support method disclosed in US4,458,066. Particularly preferred is the ph...
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