Andrographolide soft capsule and preparing method thereof

A technology of andrographolide and soft capsule, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of inconvenience in carrying and administration, slow release of tablets, and inability to take effect in time, etc. problems, to achieve beneficial properties, ease of swallowing, stability and enhancement

Active Publication Date: 2004-09-15
XIAN CHIHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] (1) Compound preparations for the respiratory system: Since a certain amount of histamine antagonists are generally added to this type of preparations, adverse reactions such as sedation, drowsiness, and fatigue are likely to occur, so the application range of this type of preparations is limited, especially for some Patients who work at heights or drive cars, boats, etc.
[0004] (2) Single drug preparations for the respiratory system: most of them are newly marketed varieties such as dioxpromazine (Kekemin), tipepidine (Ansouling), ipratone (Yikezine), phenproperone Phenyl (cough fast and good), etc., have the advantages of strong pertinence and small side effects, but because of th

Method used

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  • Andrographolide soft capsule and preparing method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Component Quantity (g / granule)

[0050] Liquid medicine: andrographolide 0.05

[0051]soybean oil 0.18

[0052] Palm oil 0.018

[0053] Hydrogenated palm oil 0.018

[0054] Beeswax 0.009

[0055] Methyl silicone oil 0.0003

[0056] Glue: Gelatin 0.3

[0057] Glycerin 0.12

[0058] Methylparaben 0.0006

Embodiment 2

[0060] Component Quantity (g / granule)

[0061] Liquid medicine: andrographolide 0.05

[0062] soybean oil 0.36

[0063] Palm oil 0.036

[0064] Hydrogenated palm oil 0.036

[0065] Beeswax 0.018

[0066] Methyl silicone oil 0.0005

[0067] Glue: Gelatin 0.4

[0068] Glycerin 0.16

[0069] Ethyl p-hydroxybenzoate 0.0008

Embodiment 3

[0071] Component Quantity (g / granule)

[0072] Liquid medicine: andrographolide 0.1

[0073] soybean oil 0.36

[0074] Palm oil 0.036

[0075] Hydrogenated palm oil 0.036

[0076] Beeswax 0.018

[0077] Dimethicone 0.0005

[0078] Glue: Gelatin 0.4

[0079] Glycerin 0.16

[0080] Methylparaben 0.0008

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Abstract

The present invention relates to an andrographolide soft capsule and its production method. Every soft capsule contains 10-300 mg of andrographolide, and contains beeswax and medicinal auxiliary material. Said medicinal auxiliary material includes diluting agent, suspension adjuvant and defoaming agent, and the interior of said capsule shell, contains (by weight ratio) 10 portions of gelatin and 4.0-5.5 portions of glycerine. Its production process includes the following steps: adding water to dissolve gelatin, adding glycerine and proper quantity of preservative, vacuum deaerating, adding suspension adjuvant into vegetable oil, mixing andrographolide, diluting agent and defoaming agent uniformly, die-pressing to obtain said invented soft capsule. Its quality is stable, administration is convenient and its effective components can be quickly resolved out.

Description

technical field [0001] The invention relates to an andrographolide soft capsule and a preparation method thereof. Background technique [0002] Upper respiratory tract infection is one of the most common diseases, among which children and the elderly have a higher incidence rate. According to statistics, in 1999, the sales of medicines used to treat upper respiratory tract infection in the world have reached 94 billion US dollars. Currently, there are such diseases on the market The drugs and their disadvantages are: [0003] (1) Compound preparations for the respiratory system: Since a certain amount of histamine antagonists are generally added to this type of preparations, adverse reactions such as sedation, drowsiness, and fatigue are likely to occur, so the application range of this type of preparations is limited, especially for some Patients who work at heights or drive cars, boats, etc. [0004] (2) Single drug preparations for the respiratory system: most of them a...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/365A61P11/00
Inventor 胡笑歌胡小虎赵宗平杨彦平程建平
Owner XIAN CHIHO PHARMA
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