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Method of extracting purified solanesol from tobacco leaf

A technology for solanesol and tobacco leaves, applied in the field of extraction and purification of solanesol, can solve the problems of high solvent use cost, increased cost, air pollution and the like

Inactive Publication Date: 2004-10-06
NORTHEAST FORESTRY UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the raw materials for extracting solanesol are all dried tobacco leaves, and most of the extraction solvents are organic solvents such as industrial n-hexane or No. 6 solvent. Compared with fresh tobacco leaf extraction, this not only increases the cost, but also degrades part of the solanesol during the drying process; 2. Due to the large consumption of extraction solvents and the low boiling point, it is not easy to recycle, resulting in high solvent usage costs , but the product cost is high, and there are fire safety hazards and serious air pollution problems at the same time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Take 100 kg of fresh tobacco leaves, add 500 kg of 70% ethanol, beat with a beater, filter the beating liquid, filter the cake with 80% ethanol for cavitation extraction, filter, and combine the filtrate with the filtrate of the aforementioned beating for concentration and saponification, and use 10 liters of saponification liquid Extract with n-hexane, wash the n-hexane extract with water until neutral, add 110 g of activated carbon for adsorption for 10 hours. Filtrate with a hollow fiber, extract the filtrate with 80% ethanol, concentrate the n-hexane phase to 1 liter, freeze and crystallize at -31°C, filter the crystals, dissolve the crystals with 6 liters of acetonitrile at 60°C, crystallize at 15°C, and use the crystals again Dissolve 4 liters of acetonitrile at 50°C and crystallize at 12°C to obtain solanesol with a purity of 95.2%, with a yield of 0.4%.

Embodiment 2

[0009] Take 100 kg of naturally dried tobacco leaves, add 600 kg of 60% ethanol, beat with a beater, filter the beating liquid, filter the cake with 70% ethanol for cavitation extraction, filter, and combine the filtrate with the filtrate of the aforementioned beating for concentration, saponification, and saponification. 20 liters of n-hexane for extraction, the n-hexane extract was washed with water until neutral, and 250 g of activated carbon was added for adsorption for 8 hours. Filter through a microporous membrane, extract the filtrate with 80% ethanol, concentrate the n-hexane phase to 2.5 liters, freeze and crystallize at -33°C, filter the crystals, dissolve the crystals with 15 liters of acetonitrile at 50°C, and crystallize at 13°C. It was then dissolved in 12 liters of acetonitrile at 53° C. and crystallized at 15° C. to obtain solanesol with a purity of 95.1%, with a yield of 0.5%.

Embodiment 3

[0011] Take 100 kg of fresh tobacco leaves, add 200 kg of 80% ethanol, beat with a beater, filter the beating liquid, filter the cake with 80% ethanol for cavitation extraction, filter, and combine the filtrate with the filtrate of the aforementioned beating for concentration and saponification, and use 15 liters of saponification liquid Extract with n-hexane, wash the n-hexane extract with water until neutral, add 98 g of activated carbon for adsorption for 12 hours. Filter through a microporous membrane, extract the filtrate with 70% ethanol, concentrate the n-hexane phase to 1.1 liters, freeze and crystallize at -27°C, filter the crystals, dissolve the crystals with 7 liters of acetonitrile at 52°C, and crystallize at 13°C. Dissolve in 5 liters of acetonitrile at 50°C and crystallize at 14°C to obtain solanesol with a purity of 95.0%, with a yield of 0.4%.

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Abstract

A process for extracting high-purity solanesol from tobacco leaf includes mixing tobacco leaf with solvent, beating, filtering slurry, vacuum extracting of filtered cake in alcohol, filtering, collecting the filtrate, concentrating, saponfiying, extracting with n-hexane, washing with water, adsorbing, filtering, extracting the filtrate in alcohol, concentrating, freezing to educe out crystal, filtering, dissolving crystal in hot acetonitrile and low-temp educing of rystal twice. Its advantages are high purity (more than 95%), high output rate and low cost.

Description

Technical field [0001] The invention relates to a method for extracting and purifying solanesol from tobacco leaves. Background technique [0002] In industry, solanesol is a synthetic coenzyme Q 10 and vitamin K 2 necessary raw materials. coenzyme Q 10 It is a natural antioxidant produced by the cells themselves, an activator of cell metabolism, and can improve the immunity of the organism. Recent studies have shown that coenzyme Q 10 It has a unique curative effect in the treatment of cardiovascular diseases, and has a significant curative effect in the treatment of scurvy, duodenal ulcer and gastric ulcer, necrotizing periodontitis, and viral hepatitis. The results of animal experiments show that coenzyme Q 10 It has anti-tumor effect, and it has a certain curative effect when used clinically to treat patients with advanced to acute cancer. Coenzyme Q 10 Tablets have been used effectively in the treatment of circular alopecia, emphysema, and to some extent in the tr...

Claims

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Application Information

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IPC IPC(8): C07C29/76C07C33/02
Inventor 祖元刚赵春建付玉杰李春英祖柏实李庆勇李雪莹焦琰
Owner NORTHEAST FORESTRY UNIVERSITY
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